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8OSK
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BU of 8osk by Molmil
Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map)
Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ...
Authors:Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2023-04-19
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
8OTS
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BU of 8ots by Molmil
OCT4 and MYC-MAX co-bound to a nucleosome
Descriptor: DNA (127-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.
Deposit date:2023-04-21
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
8OSJ
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BU of 8osj by Molmil
Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1)
Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ...
Authors:Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2023-04-19
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
4WSN
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BU of 4wsn by Molmil
Crystal structure of the COP9 signalosome, a P1 crystal form
Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Bunker, R.D, Lingaraju, G.M, Thoma, N.H.
Deposit date:2014-10-28
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Nature, 531, 2016
9EOQ
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BU of 9eoq by Molmil
Cryo-EM Structure of a 1033 Scaffold Base DNA Origami Nanostructure V4 and TBA
Descriptor: DNA (42-MER), DNA (5'-D(P*AP*TP*AP*TP*AP*GP*CP*GP*TP*GP*GP*AP*AP*GP*T)-3')
Authors:Ali, K, Georg, K, Volodymyr, M, Johanna, G, Maximilian, N.H, Lukas, K, Simone, C, Hendrik, D.
Deposit date:2024-03-15
Release date:2024-04-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:Designing Rigid DNA Origami Templates for Molecular Visualization Using Cryo-EM.
Nano Lett., 24, 2024
5NW5
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BU of 5nw5 by Molmil
Crystal structure of the Rif1 N-terminal domain (RIF1-NTD) from Saccharomyces cerevisiae in complex with DNA
Descriptor: DNA (30-MER), DNA (60-MER), Telomere length regulator protein RIF1
Authors:Bunker, R.D, Reinert, J.K, Shi, T, Thoma, N.H.
Deposit date:2017-05-05
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (6.502 Å)
Cite:Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.
Nat. Struct. Mol. Biol., 24, 2017
5NVR
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BU of 5nvr by Molmil
Crystal structure of the Rif1 N-terminal domain (RIF1-NTD) from Saccharomyces cerevisiae
Descriptor: Telomere length regulator protein RIF1
Authors:Bunker, R.D, Shi, T, Thoma, N.H.
Deposit date:2017-05-04
Release date:2017-06-14
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.
Nat. Struct. Mol. Biol., 24, 2017
7BHP
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BU of 7bhp by Molmil
Cryo-EM structure of the human Ebp1 - 80S ribosome
Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Desogus, J, Bhaskar, V, Chao, J.A.
Deposit date:2021-01-11
Release date:2021-02-03
Last modified:2021-03-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Dynamic association of human Ebp1 with the ribosome.
Rna, 27, 2021
7NJ0
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BU of 7nj0 by Molmil
CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex
Descriptor: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1, G2/mitotic-specific cyclin-B1,G2/mitotic-specific cyclin-B1, ...
Authors:Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A.
Deposit date:2021-02-14
Release date:2021-08-04
Last modified:2021-08-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Nature, 596, 2021
7NJ1
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BU of 7nj1 by Molmil
CryoEM structure of the human Separase-Securin complex
Descriptor: Securin, Separin
Authors:Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A.
Deposit date:2021-02-14
Release date:2021-08-04
Last modified:2021-08-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Nature, 596, 2021
4A0L
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BU of 4a0l by Molmil
Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex
Descriptor: 12 BP DNA DUPLEX, 12 BP THF CONTAINING DNA DUPLEX, CULLIN-4B, ...
Authors:Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H.
Deposit date:2011-09-09
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (7.4 Å)
Cite:The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
4A0K
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BU of 4a0k by Molmil
STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX
Descriptor: 12 BP DNA, 12 BP THF CONTAINING DNA, CULLIN-4A, ...
Authors:Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H.
Deposit date:2011-09-09
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (5.93 Å)
Cite:The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
4A11
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BU of 4a11 by Molmil
Structure of the hsDDB1-hsCSA complex
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, DNA EXCISION REPAIR PROTEIN ERCC-8
Authors:Bohm, K, Scrima, A, Fischer, E.S, Gut, H, Thomae, N.H.
Deposit date:2011-09-13
Release date:2011-12-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
6GVW
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BU of 6gvw by Molmil
Crystal structure of the BRCA1-A complex
Descriptor: BRCA1-A complex subunit Abraxas 1, BRCA1-A complex subunit RAP80, BRISC and BRCA1-A complex member 1, ...
Authors:Bunker, R.D, Rabl, J, Thoma, N.H.
Deposit date:2018-06-21
Release date:2019-07-10
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Mol.Cell, 75, 2019
6H3C
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BU of 6h3c by Molmil
Cryo-EM structure of the BRISC complex bound to SHMT2
Descriptor: BRISC and BRCA1-A complex member 1, BRISC and BRCA1-A complex member 2, BRISC complex subunit Abraxas 2, ...
Authors:Bunker, R.D, Rabl, J, Thoma, N.H.
Deposit date:2018-07-18
Release date:2019-07-10
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Mol.Cell, 75, 2019
4CHT
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BU of 4cht by Molmil
Crystal structure of the human topoisomerase III alpha-RMI1 complex with bound calcium ion
Descriptor: CALCIUM ION, DNA TOPOISOMERASE 3-ALPHA, RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1
Authors:Bocquet, N, Bunker, R.D, Thoma, N.H.
Deposit date:2013-12-04
Release date:2014-02-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1
Nat.Struct.Mol.Biol., 21, 2014
4CI3
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BU of 4ci3 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4D10
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BU of 4d10 by Molmil
Crystal structure of the COP9 signalosome
Descriptor: COP9 SIGNALOSOME COMPLEX SUBUNIT 1, COP9 SIGNALOSOME COMPLEX SUBUNIT 2, COP9 SIGNALOSOME COMPLEX SUBUNIT 3, ...
Authors:Bunker, R.D, Lingaraju, G.M, Thoma, N.H.
Deposit date:2014-04-30
Release date:2014-07-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal Structure of the Human Cop9 Signalosome
Nature, 512, 2014
4D18
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BU of 4d18 by Molmil
Crystal structure of the COP9 signalosome
Descriptor: COP9 SIGNALOSOME COMPLEX SUBUNIT 1, COP9 SIGNALOSOME COMPLEX SUBUNIT 2, COP9 SIGNALOSOME COMPLEX SUBUNIT 3, ...
Authors:Bunker, R.D, Lingaraju, G.M, Thoma, N.H.
Deposit date:2014-05-01
Release date:2014-07-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (4.08 Å)
Cite:Crystal Structure of the Human Cop9 Signalosome
Nature, 512, 2014
4D0P
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BU of 4d0p by Molmil
Crystal structure of human CSN4
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, COP9 SIGNALOSOME COMPLEX SUBUNIT 4, ...
Authors:Bunker, R.D, Lingaraju, G.M, Thoma, N.H.
Deposit date:2014-04-29
Release date:2014-07-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of the Cop9 Signalosome
Nature, 512, 2014
4CGY
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BU of 4cgy by Molmil
Crystal structure of the human topoisomerase III alpha-RMI1 complex
Descriptor: DNA TOPOISOMERASE 3-ALPHA, MAGNESIUM ION, RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1
Authors:Bocquet, N, Bunker, R.D, Thoma, N.H.
Deposit date:2013-11-27
Release date:2014-02-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1
Nat.Struct.Mol.Biol., 21, 2014
4CI1
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BU of 4ci1 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4CI2
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BU of 4ci2 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
8P82
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BU of 8p82 by Molmil
Cryo-EM structure of dimeric UBR5
Descriptor: E3 ubiquitin-protein ligase UBR5, ZINC ION
Authors:Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2023-05-31
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability
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