6OD4
 
 | | Human TCF4 C-terminal bHLH domain in Complex with 11-bp Oligonucleotide Containing E-box Sequence | | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*AP*CP*AP*CP*GP*TP*GP*TP*A)-3'), Transcription factor 4 | | Authors: | Horton, J.R, Cheng, X, Yang, J. | | Deposit date: | 2019-03-25 | | Release date: | 2019-05-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.699 Å) | | Cite: | Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.
Nucleic Acids Res., 47, 2019
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6OAO
 | | Structure of DBP in complex with human neutralizing antibody 092096 | | Descriptor: | Antibody 092096 single chain variable fragment, Duffy binding surface protein region II, SULFATE ION | | Authors: | Urusova, D, Tolia, N.H. | | Deposit date: | 2019-03-18 | | Release date: | 2019-06-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.497 Å) | | Cite: | Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
Nat Microbiol, 4, 2019
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7BRM
 | | Architecture of curli complex | | Descriptor: | Curli production assembly/transport protein CsgG, csgf | | Authors: | Zhang, M, Shi, H. | | Deposit date: | 2020-03-29 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of the nonameric CsgG-CsgF complex and its implications for controlling curli biogenesis in Enterobacteriaceae.
Plos Biol., 18, 2020
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6OD3
 | | Human TCF4 C-terminal bHLH domain in Complex with 13-bp Oligonucleotide Containing E-box Sequence | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*AP*TP*AP*CP*AP*CP*GP*TP*GP*TP*AP*T)-3'), ... | | Authors: | Horton, J.R, Cheng, X, Yang, J. | | Deposit date: | 2019-03-25 | | Release date: | 2019-05-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.494 Å) | | Cite: | Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.
Nucleic Acids Res., 47, 2019
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5ZZ2
 | | Crystal structure of PDE5 in complex with inhibitor LW1634 | | Descriptor: | 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ... | | Authors: | Wu, D, Huang, Y.D, Huang, Y.Y, Luo, H.B. | | Deposit date: | 2018-05-29 | | Release date: | 2018-09-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.
J. Med. Chem., 61, 2018
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3AQS
 | | Crystal structure of RolR (NCGL1110) without ligand | | Descriptor: | Bacterial regulatory proteins, tetR family | | Authors: | Li, D.F, Zhang, N, Hou, Y.J, Liu, S.J, Wang, D.C. | | Deposit date: | 2010-11-18 | | Release date: | 2011-07-06 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Crystal structures of the transcriptional repressor RolR reveals a novel recognition mechanism between inducer and regulator.
Plos One, 6, 2011
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5WUK
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3AQT
 | | CRYSTAL STRUCTURE OF RolR (NCGL1110) complex WITH ligand RESORCINOL | | Descriptor: | Bacterial regulatory proteins, tetR family, RESORCINOL | | Authors: | Li, D.F, Zhang, N, Hou, Y.J, Liu, S.J, Wang, D.C. | | Deposit date: | 2010-11-18 | | Release date: | 2011-07-06 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of the transcriptional repressor RolR reveals a novel recognition mechanism between inducer and regulator.
Plos One, 6, 2011
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4Q2W
 | | Crystal Structure of pneumococcal peptidoglycan hydrolase LytB | | Descriptor: | GLYCEROL, Putative endo-beta-N-acetylglucosaminidase | | Authors: | Bai, X.H, Chen, H.J, Jiang, Y.L, Wen, Z, Cheng, W, Li, Q, Zhang, J.R, Chen, Y, Zhou, C.Z. | | Deposit date: | 2014-04-10 | | Release date: | 2014-07-16 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis.
J.Biol.Chem., 289, 2014
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5CHL
 | | Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex | | Descriptor: | Histone H2A.Z, Vacuolar protein sorting-associated protein 72 homolog | | Authors: | Shan, S, Liang, X, Pan, L, Wu, C, Zhou, Z. | | Deposit date: | 2015-07-10 | | Release date: | 2016-03-09 | | Last modified: | 2017-09-27 | | Method: | X-RAY DIFFRACTION (1.892 Å) | | Cite: | Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1
Nat.Struct.Mol.Biol., 23, 2016
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6SVL
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6SVK
 | | human Myeloid-derived growth factor (MYDGF) | | Descriptor: | MALONATE ION, Myeloid-derived growth factor | | Authors: | Ebenhoch, R, Nar, H. | | Deposit date: | 2019-09-18 | | Release date: | 2019-11-27 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (1.604 Å) | | Cite: | Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair.
Nat Commun, 10, 2019
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3STO
 | | Serpin from the trematode Schistosoma Haematobium | | Descriptor: | Serine protease inhibitor | | Authors: | Granzin, J, Weiergraeber, O.H, Lee, X, Blanton, R.E. | | Deposit date: | 2011-07-11 | | Release date: | 2012-05-30 | | Last modified: | 2013-01-23 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain.
Acta Crystallogr.,Sect.D, 68, 2012
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5GQ0
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3LON
 | | HCV NS3-4a protease domain with ketoamide inhibitor narlaprevir | | Descriptor: | (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropylamino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, BETA-MERCAPTOETHANOL, Genome polyprotein, ... | | Authors: | Prongay, A.J. | | Deposit date: | 2010-02-04 | | Release date: | 2011-01-19 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Candidate selection and preclinical evaluation culminating in the discovery of Narlaprevir (SCH 900518): A potent, selective and orally efficacious second generation HCV NS3 serine protease inhibitor
To be Published
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2NZ0
 | | Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 | | Descriptor: | CALCIUM ION, Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 3, ... | | Authors: | Wang, H, Yan, Y, Shen, Y, Chen, L, Wang, K. | | Deposit date: | 2006-11-22 | | Release date: | 2006-12-26 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural basis for modulation of Kv4 K(+) channels by auxiliary KChIP subunits.
Nat.Neurosci., 10, 2007
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3O7P
 | | Crystal structure of the E.coli Fucose:proton symporter, FucP (N162A) | | Descriptor: | L-fucose-proton symporter, nonyl beta-D-glucopyranoside | | Authors: | Dang, S.Y, Sun, L.F, Wang, J, Yan, N. | | Deposit date: | 2010-07-30 | | Release date: | 2010-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.196 Å) | | Cite: | Structure of a fucose transporter in an outward-open conformation
Nature, 467, 2010
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3O7Q
 | | Crystal structure of a Major Facilitator Superfamily (MFS) transporter, FucP, in the outward conformation | | Descriptor: | L-fucose-proton symporter, nonyl beta-D-glucopyranoside | | Authors: | Sun, L.F, Dang, S.Y, Wang, J, Yan, N. | | Deposit date: | 2010-07-30 | | Release date: | 2010-09-15 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.143 Å) | | Cite: | Structure of a fucose transporter in an outward-open conformation
Nature, 467, 2010
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8H1S
 | | Crystal structure of apo-LptDE complex | | Descriptor: | LPS-assembly lipoprotein LptE, LPS-assembly protein LptD | | Authors: | Luo, Q, Huang, Y. | | Deposit date: | 2022-10-03 | | Release date: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.28 Å) | | Cite: | Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis
To Be Published
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8H1R
 | | Crystal structure of LptDE-YifL complex | | Descriptor: | (2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE, LPS-assembly lipoprotein LptE, LPS-assembly protein LptD, ... | | Authors: | Luo, Q, Huang, Y. | | Deposit date: | 2022-10-03 | | Release date: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis
To Be Published
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8IEN
 | | Cryo-EM structure of ATP13A2 in the E2-Pi state | | Descriptor: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | Deposit date: | 2023-02-15 | | Release date: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IEM
 | | Cryo-EM structure of ATP13A2 in the E2P state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | Deposit date: | 2023-02-15 | | Release date: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IEL
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8IEO
 | | Cryo-EM structure of ATP13A2 in the nominal E1P state | | Descriptor: | MAGNESIUM ION, Polyamine-transporting ATPase 13A2, SPERMINE, ... | | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | Deposit date: | 2023-02-15 | | Release date: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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8IES
 | | Cryo-EM structure of ATP13A2 in the E1P-ADP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Polyamine-transporting ATPase 13A2, ... | | Authors: | Liu, Z.M, Mu, J.Q, Xue, C.Y. | | Deposit date: | 2023-02-15 | | Release date: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.73 Å) | | Cite: | Conformational cycle of human polyamine transporter ATP13A2.
Nat Commun, 14, 2023
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