6JUT

Crystal structure of ZAK in complex with compound 6k

Summary for 6JUT

Entry DOI	10.2210/pdb6jut/pdb
Descriptor	Mitogen-activated protein kinase kinase kinase MLT, ~{N}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{H}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]-3-bromanyl-benzenesulfonamide (3 entities in total)
Functional Keywords	zak, inhibitor, structural protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35899.85
Authors	Kong, L.L.,Yun, C.H. (deposition date: 2019-04-15, release date: 2019-07-24, Last modification date: 2023-11-22)
Primary citation	Yang, J.,Shibu, M.A.,Kong, L.,Luo, J.,BadrealamKhan, F.,Huang, Y.,Tu, Z.C.,Yun, C.H.,Huang, C.Y.,Ding, K.,Lu, X. Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors. J.Med.Chem., 63:2114-2130, 2020 Cited by PubMed: 31244114 DOI: 10.1021/acs.jmedchem.9b00664 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation