6JUT
Crystal structure of ZAK in complex with compound 6k
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue C9O A 401 |
| Chain | Residue |
| A | CYS22 |
| A | TYR84 |
| A | ALA85 |
| A | GLY88 |
| A | CYS150 |
| A | ASP151 |
| A | PHE152 |
| A | GLY153 |
| A | PHE157 |
| A | HOH503 |
| A | HOH588 |
| A | VAL30 |
| A | ALA43 |
| A | LYS45 |
| A | ALA54 |
| A | SER58 |
| A | PHE68 |
| A | ILE80 |
| A | THR82 |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDLKsrNVVI |
| Chain | Residue | Details |
| A | VAL129-ILE141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P80192, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP133 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P80192, ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | CYS22 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:11836244 |
| Chain | Residue | Details |
| A | LYS45 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:32289254 |
| Chain | Residue | Details |
| A | SER7 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:26999302 |
| Chain | Residue | Details |
| A | THR161 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:26999302 |
| Chain | Residue | Details |
| A | SER165 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER275 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:32289254, ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | SER302 |
