6JRX

EGFR T790M/C797S in complex with compound 6i

Summary for 6JRX

Entry DOI	10.2210/pdb6jrx/pdb
Descriptor	Epidermal growth factor receptor, N-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]cyclohexyl}propanamide (3 entities in total)
Functional Keywords	egfr t790m/c797s, inhibitor, complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	38251.72
Authors	Zhu, S.J.,Yun, C.H. (deposition date: 2019-04-06, release date: 2020-04-15, Last modification date: 2024-03-27)
Primary citation	Yang, J.,Shibu, M.A.,Kong, L.,Luo, J.,BadrealamKhan, F.,Huang, Y.,Tu, Z.C.,Yun, C.H.,Huang, C.Y.,Ding, K.,Lu, X. Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors. J.Med.Chem., 63:2114-2130, 2020 Cited by PubMed: 31244114 DOI: 10.1021/acs.jmedchem.9b00664 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.201 Å)

Structure validation