7QEN
 
 | | S.c. Condensin core in DNA- and ATP-bound state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Condensin complex subunit 1, Condensin complex subunit 2, ... | | Authors: | Lecomte, L, Hassler, M, Haering, C, Eustermann, S. | | Deposit date: | 2021-12-03 | | Release date: | 2022-06-15 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | A hold-and-feed mechanism drives directional DNA loop extrusion by condensin.
Science, 376, 2022
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7QFW
 | | S.c. Condensin peripheral Ycg1 subcomplex bound to DNA | | Descriptor: | Condensin complex subunit 2, Condensin complex subunit 3, Synthetic DNA ligand, ... | | Authors: | Lecomte, L, Hassler, M, Haering, C, Eustermann, S. | | Deposit date: | 2021-12-06 | | Release date: | 2022-06-15 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.86 Å) | | Cite: | A hold-and-feed mechanism drives directional DNA loop extrusion by condensin.
Science, 376, 2022
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7TCQ
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5M5A
 | | Crystal structure of MELK in complex with an inhibitor | | Descriptor: | CHLORIDE ION, K-252A, Maternal embryonic leucine zipper kinase, ... | | Authors: | Canevari, G, Re Depaolini, S, Casale, E, Felder, E, Kuster, B, Heinzlmeir, S. | | Deposit date: | 2016-10-21 | | Release date: | 2017-12-06 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The target landscape of clinical kinase drugs.
Science, 358, 2017
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6AMB
 | | Crystal Structure of the Afadin RA1 domain in complex with HRAS | | Descriptor: | Afadin, GTPase HRas, MAGNESIUM ION, ... | | Authors: | Smith, M.J, Ishiyama, N, Ikura, M. | | Deposit date: | 2017-08-09 | | Release date: | 2017-11-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.
Nat Commun, 8, 2017
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2LLJ
 | | Structure of a bis-naphthalene bound to a thymine-thymine DNA mismatch | | Descriptor: | 6,22-dioxa-3,9,19,25-tetraazoniapentacyclo[25.5.3.3~11,17~.0~14,37~.0~30,34~]octatriaconta-1(33),11(38),12,14(37),15,17(36),27,29,31,34-decaene, DNA (5'-D(*CP*GP*TP*CP*GP*TP*AP*GP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*CP*TP*TP*CP*GP*AP*CP*G)-3') | | Authors: | Jourdan, M, Granzhan, A, Guillot, R, Dumy, P, Teulade-Fichou, M. | | Deposit date: | 2011-11-10 | | Release date: | 2013-02-20 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Double threading through DNA: NMR structural study of a bis-naphthalene macrocycle bound to a thymine-thymine mismatch.
Nucleic Acids Res., 40, 2012
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6CNV
 | | INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR9114 Fab heavy chain, ... | | Authors: | Luo, J, Obmolova, G. | | Deposit date: | 2018-03-09 | | Release date: | 2018-11-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
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6CK8
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5E37
 | | Redox protein from Chlamydomonas reinhardtii | | Descriptor: | CALCIUM ION, EF-Hand domain-containing thioredoxin | | Authors: | Charoenwattansatien, R, Hochmal, A.K, Zinzius, K, Muto, R, Tanaka, H, Hippler, M, Kurisu, G. | | Deposit date: | 2015-10-02 | | Release date: | 2016-06-22 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Calredoxin represents a novel type of calcium-dependent sensor-responder connected to redox regulation in the chloroplast
Nat Commun, 7, 2016
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6C6Z
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6CNW
 | | STRUCTURE OF HUMANIZED SINGLE DOMAIN ANTIBODY SD84 | | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, humanized antibody SD84h | | Authors: | Luo, J, Obmolova, O. | | Deposit date: | 2018-03-09 | | Release date: | 2018-11-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (0.92 Å) | | Cite: | Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
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6C6Y
 | | Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque in complex with MERS Receptor Binding Domain | | Descriptor: | JC57-14 Heavy chain, JC57-14 Light chain, SULFATE ION, ... | | Authors: | Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D. | | Deposit date: | 2018-01-19 | | Release date: | 2018-03-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.32 Å) | | Cite: | Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.
J. Virol., 92, 2018
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6C6X
 | | Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque. | | Descriptor: | JC57-14 Heavy chain, JC57-14 Light chain | | Authors: | Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D. | | Deposit date: | 2018-01-19 | | Release date: | 2018-02-28 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.
J. Virol., 92, 2018
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8ACK
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8ACR
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8ACG
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8AC7
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8AC9
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1EAH
 | | PV2L COMPLEXED WITH ANTIVIRAL AGENT SCH48973 | | Descriptor: | 1[2-CHLORO-4-METHOXY-PHENYL-OXYMETHYL]-4-[2,6-DICHLORO-PHENYL-OXYMETHYL]-BENZENE, MYRISTIC ACID, POLIOVIRUS TYPE 2 COAT PROTEINS VP1 TO VP4 | | Authors: | Lentz, K, Arnold, E. | | Deposit date: | 1997-07-22 | | Release date: | 1998-09-16 | | Last modified: | 2023-04-19 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes.
Structure, 5, 1997
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7ALM
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1X9Y
 | | The prostaphopain B structure | | Descriptor: | cysteine proteinase | | Authors: | Filipek, R, Szczepanowski, R, Sabat, A, Potempa, J, Bochtler, M. | | Deposit date: | 2004-08-24 | | Release date: | 2004-11-23 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Prostaphopain B structure: a comparison of proregion-mediated and staphostatin-mediated protease inhibition.
Biochemistry, 43, 2004
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6FYT
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5NIU
 | | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor | | Descriptor: | (2~{R})-2-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]-5-methyl-phenyl]methylamino]-3-oxidanyl-propanoic acid, 1,2-ETHANEDIOL, Programmed cell death 1 ligand 1 | | Authors: | Zak, K.M, Grudnik, P, Skalniak, L, Dubin, G, Holak, T.A. | | Deposit date: | 2017-03-27 | | Release date: | 2017-12-06 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
Oncotarget, 8, 2017
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5NNC
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac) | | Descriptor: | Bromodomain-containing protein 4, Histone H3 | | Authors: | Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C. | | Deposit date: | 2017-04-08 | | Release date: | 2018-05-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
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5NNG
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SRPK1 peptide (K585ac) | | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, VAG(ALY)YS(ALY)EFFY | | Authors: | Filippakopoulos, P, Picaud, S, Newman, J, Sorrell, F, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-04-08 | | Release date: | 2018-05-16 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
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