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5NNG

Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SRPK1 peptide (K585ac)

Summary for 5NNG
Entry DOI10.2210/pdb5nng/pdb
DescriptorBromodomain-containing protein 4, VAG(ALY)YS(ALY)EFFY, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsbromodomain, transcription, complex, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight16646.10
Authors
Filippakopoulos, P.,Picaud, S.,Newman, J.,Sorrell, F.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Structural Genomics Consortium (SGC) (deposition date: 2017-04-08, release date: 2018-05-16, Last modification date: 2024-01-17)
Primary citationLambert, J.P.,Picaud, S.,Fujisawa, T.,Hou, H.,Savitsky, P.,Uuskula-Reimand, L.,Gupta, G.D.,Abdouni, H.,Lin, Z.Y.,Tucholska, M.,Knight, J.D.R.,Gonzalez-Badillo, B.,St-Denis, N.,Newman, J.A.,Stucki, M.,Pelletier, L.,Bandeira, N.,Wilson, M.D.,Filippakopoulos, P.,Gingras, A.C.
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73:621-638.e17, 2019
Cited by
PubMed: 30554943
DOI: 10.1016/j.molcel.2018.11.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.2 Å)
Structure validation

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