5NNG

Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SRPK1 peptide (K585ac)

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 201

Chain	Residue
A	ILE100
A	ILE101
A	LYS102
A	THR103
A	ASN135
B	GLU589

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site_id	AC2
Number of Residues	1
Details	binding site for residue EDO A 202

Chain	Residue
A	LYS160

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site_id	AC3
Number of Residues	8
Details	binding site for Ligand residues ALY B 588 through GLU B 589 bound to SER B 587

Chain	Residue
B	VAL582
B	TYR586
B	SER587
B	PHE590
B	HOH608
B	HOH609
A	ASN93
A	EDO201

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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