8TVP
 
 | | Cryo-EM structure of CPD-stalled Pol II in complex with Rad26 (open state) | | Descriptor: | DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ... | | Authors: | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | Deposit date: | 2023-08-18 | | Release date: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVY
 | | Cryo-EM structure of CPD lesion containing RNA Polymerase II elongation complex with Rad26 and Elf1 (closed state) | | Descriptor: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | Deposit date: | 2023-08-18 | | Release date: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6WJC
 | | Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex | | Descriptor: | (1R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL (2R)-3-HYDROXY-2-PHENYLPROPANOATE, ACETAMIDE, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Maeda, S, Kobilka, B.K. | | Deposit date: | 2020-04-13 | | Release date: | 2020-07-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structure and selectivity engineering of the M1muscarinic receptor toxin complex.
Science, 369, 2020
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7AXU
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7AXQ
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7AXX
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7AXP
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7AXS
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7KDT
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8HIH
 | | Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex with transcription factor GlnR | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Lin, W, Shi, J, Xu, J.C. | | Deposit date: | 2022-11-20 | | Release date: | 2023-06-07 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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4ZS3
 | | Structural complex of 5-aminofluorescein bound to the FTO protein | | Descriptor: | 2-OXOGLUTARIC ACID, 5-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | | Authors: | Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X. | | Deposit date: | 2015-05-13 | | Release date: | 2015-11-04 | | Last modified: | 2015-11-18 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein
J.Am.Chem.Soc., 137, 2015
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4ZS2
 | | Structural complex of FTO/fluorescein | | Descriptor: | 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID, 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | | Authors: | Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X. | | Deposit date: | 2015-05-13 | | Release date: | 2015-11-04 | | Last modified: | 2015-11-18 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein
J.Am.Chem.Soc., 137, 2015
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8TGH
 | | VMAT1 dimer with amphetamine and reserpine | | Descriptor: | (2S)-1-phenylpropan-2-amine, Chromaffin granule amine transporter, reserpine | | Authors: | Ye, J, Liu, B, Li, W. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-20 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGJ
 | | VMAT1 dimer in unbound form and with reserpine | | Descriptor: | VMAT1 dimer in unbound form and with reserpine, reserpine | | Authors: | Ye, J, Liu, B, Li, W. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-20 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGG
 | | VMAT1 dimer with MPP+ and reserpine | | Descriptor: | 1-methyl-4-phenylpyridin-1-ium, Chromaffin granule amine transporter, reserpine | | Authors: | Ye, J, Liu, B, Li, W. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-20 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGI
 | | VMAT1 dimer with dopamine and reserpine | | Descriptor: | Chromaffin granule amine transporter, L-DOPAMINE, reserpine | | Authors: | Ye, J, Liu, B, Li, W. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-20 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGL
 | | VMAT1 dimer with norepinephrine and reserpine | | Descriptor: | Chromaffin granule amine transporter, L-NOREPINEPHRINE, reserpine | | Authors: | Ye, J, Liu, B, Li, W. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-20 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8HML
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4ZJB
 | | Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) in complex with holo-ACP from Helicobacter pylori | | Descriptor: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, 4'-PHOSPHOPANTETHEINE, Acyl carrier protein, ... | | Authors: | Zhang, L, Zhang, L, Shen, X, Jiang, H. | | Deposit date: | 2015-04-29 | | Release date: | 2016-11-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis.
Cell Res., 26, 2016
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8TGM
 | | VMAT1 dimer with reserpine | | Descriptor: | VMAT1 dimer with reserpine, reserpine | | Authors: | Ye, J, Liu, B, Li, W. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-20 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGN
 | | VMAT1 dimer with serotonin and reserpine | | Descriptor: | Chromaffin granule amine transporter, SEROTONIN, reserpine | | Authors: | Ye, J, Liu, B, Li, W. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-20 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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8TGK
 | | VMAT1 dimer with histamine and reserpine | | Descriptor: | Chromaffin granule amine transporter, HISTAMINE, reserpine | | Authors: | Ye, J, Liu, B, Li, W. | | Deposit date: | 2023-07-12 | | Release date: | 2024-03-20 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural insights into vesicular monoamine storage and drug interactions.
Nature, 629, 2024
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6KRC
 | | An X-ray structure of ferric F43Y/F46S sperm whale myoglobin | | Descriptor: | Myoglobin, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Yuan, H, Lin, Y.W. | | Deposit date: | 2019-08-21 | | Release date: | 2020-07-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | A Catalytic Binding Site Together with a Distal Tyr in MyoglobinAffords Catalytic Efficiencies Similar to Natural Peroxidases.
Acs Catalysis, 10, 2020
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8T7H
 | | Quis-bound intermediate mGlu5 | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nanobody 43 | | Authors: | Krishna Kumar, K, Wang, H, Kobilka, B.K. | | Deposit date: | 2023-06-20 | | Release date: | 2023-10-11 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
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8T8M
 | | Quis-bound intermediate mGlu5 | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nb43 | | Authors: | Krishna Kumar, K, Wang, H, Kobilka, B.K. | | Deposit date: | 2023-06-22 | | Release date: | 2023-10-11 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
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