1NOQ
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![BU of 1noq by Molmil](/molmil-images/mine/1noq) | e-motif structure | 分子名称: | 5'-D(*CP*CP*GP*CP*CP*G)-3' | 著者 | Zheng, M, Huang, X, Smith, G.K, Yang, X, Gao, X. | 登録日 | 2003-01-16 | 公開日 | 2003-02-11 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding.
An NMR and UV spectroscopic study. J.Mol.Biol., 264, 1996
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1NP5
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![BU of 1np5 by Molmil](/molmil-images/mine/1np5) | (GAC)3 parallel duplex | 分子名称: | 5'-D(*GP*AP*CP*GP*AP*CP*GP*AP*C)-3' | 著者 | Zheng, M, Han, X, Gao, X. | 登録日 | 2003-01-17 | 公開日 | 2003-02-11 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Strand polarity of trinucleotide repeat sequences:
NMR studies of parallel/anti-pararell duplex,{d(GAC)3}2 To be Published
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3FMS
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![BU of 3fms by Molmil](/molmil-images/mine/3fms) | Crystal structure of TM0439, a GntR transcriptional regulator | 分子名称: | ACETATE ION, NICKEL (II) ION, Transcriptional regulator, ... | 著者 | Zheng, M, Cooper, D.R, Yu, M, Hung, L.-W, Derewenda, U, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI) | 登録日 | 2008-12-22 | 公開日 | 2009-02-10 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains. Acta Crystallogr.,Sect.D, 65, 2009
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6V1V
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![BU of 6v1v by Molmil](/molmil-images/mine/6v1v) | VIP3B (VIP3B_2160) adapted for crystallization | 分子名称: | Vegetative insecticidal protein | 著者 | Evdokimov, A.G, Zheng, M, Moshiri, F, Haas, J, Lowder, C. | 登録日 | 2019-11-21 | 公開日 | 2019-12-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.189 Å) | 主引用文献 | Crystal structure of a Vip3B family insecticidal protein reveals a new fold and a unique tetrameric assembly. Protein Sci., 29, 2020
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3QOR
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4W8J
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![BU of 4w8j by Molmil](/molmil-images/mine/4w8j) | Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals | 分子名称: | CALCIUM ION, POTASSIUM ION, Pesticidal crystal protein cry1Ac | 著者 | Evdokimov, A.G, Moshiri, F, Sturman, E.J, Rydel, T.J, Zheng, M, Seale, J.W, Franklin, S. | 登録日 | 2014-08-25 | 公開日 | 2014-09-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals. Protein Sci., 23, 2014
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6D0O
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![BU of 6d0o by Molmil](/molmil-images/mine/6d0o) | rdpA dioxygenase holoenzyme | 分子名称: | (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase, 2-OXOGLUTARIC ACID, COBALT (II) ION | 著者 | Rydel, T.J, Sturman, E.J, Zheng, M, Evdokimov, A. | 登録日 | 2018-04-10 | 公開日 | 2018-08-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Development of enzymes for robust aryloxyphenoxypropionate and synthetic auxin herbicide tolerance traits in maize and soybean crops. Pest Manag. Sci., 75, 2019
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2A7R
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![BU of 2a7r by Molmil](/molmil-images/mine/2a7r) | Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2) | 分子名称: | GMP reductase 2, GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION | 著者 | Li, J, Wei, Z, Zheng, M, Gu, X, Deng, Y, Qiu, R, Chen, F, Ji, C, Gong, W, Xie, Y, Mao, Y. | 登録日 | 2005-07-05 | 公開日 | 2006-01-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structure of Human Guanosine Monophosphate Reductase 2 (GMPR2) in Complex with GMP J.Mol.Biol., 355, 2006
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1WPB
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![BU of 1wpb by Molmil](/molmil-images/mine/1wpb) | Structure of Escherichia coli yfbU gene product | 分子名称: | CHLORIDE ION, GLYCEROL, hypothetical protein yfbU | 著者 | Borek, D, Chen, Y, Zheng, M, Skarina, T, Savchenko, A, Edwards, A, Otwinowski, Z, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2004-09-01 | 公開日 | 2004-12-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of Escherichia coli yfbU gene product To be Published
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7MJR
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![BU of 7mjr by Molmil](/molmil-images/mine/7mjr) | Vip4Da2 toxin structure | 分子名称: | CALCIUM ION, SULFATE ION, Vip4Da1 protein | 著者 | Rydel, T.J, Duda, D, Zheng, M, Henry, A. | 登録日 | 2021-04-20 | 公開日 | 2021-05-05 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Structural and functional insights into the first Bacillus thuringiensis vegetative insecticidal protein of the Vpb4 fold, active against western corn rootworm. Plos One, 16, 2021
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7ML9
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![BU of 7ml9 by Molmil](/molmil-images/mine/7ml9) | The Mpp75Aa1.1 beta-pore-forming protein from Brevibacillus laterosporus | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Insecticidal protein, ... | 著者 | Rydel, T.J, Zheng, M, Evdokimov, A. | 登録日 | 2021-04-27 | 公開日 | 2021-05-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural and functional characterization of Mpp75Aa1.1, a putative beta-pore forming protein from Brevibacillus laterosporus active against the western corn rootworm. Plos One, 16, 2021
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5ZYQ
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![BU of 5zyq by Molmil](/molmil-images/mine/5zyq) | The Structure of Human PAF1/CTR9 complex | 分子名称: | RNA polymerase-associated protein CTR9 homolog,RNA polymerase II-associated factor 1 homolog | 著者 | Xie, Y, Zheng, M, Zhou, H, Long, J. | 登録日 | 2018-05-28 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.531 Å) | 主引用文献 | Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation. Nat Commun, 9, 2018
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5ZYP
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![BU of 5zyp by Molmil](/molmil-images/mine/5zyp) | Structure of the Yeast Ctr9/Paf1 complex | 分子名称: | NICKEL (II) ION, RNA polymerase-associated protein CTR9,RNA polymerase II-associated protein 1 | 著者 | Xie, Y, Zheng, M, Zhou, H, Long, J. | 登録日 | 2018-05-28 | 公開日 | 2018-09-26 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (2.532 Å) | 主引用文献 | Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation. Nat Commun, 9, 2018
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6LN1
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![BU of 6ln1 by Molmil](/molmil-images/mine/6ln1) | A natural inhibitor of DYRK1A for treatment of diabetes mellitus | 分子名称: | 1,3,5,8-tetrakis(oxidanyl)xanthen-9-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 著者 | Li, H, Chen, L.X, Zheng, M.Z, Zhang, Q.Z, Zhang, C.L, Wu, C.R, Yang, K.Y, Song, Z.R, Wang, Q.Q, Li, C, Zhou, Y.R, Chen, J.C. | 登録日 | 2019-12-28 | 公開日 | 2021-10-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.699 Å) | 主引用文献 | A natural DYRK1A inhibitor as a potential stimulator for beta-cell proliferation in diabetes. Clin Transl Med, 11, 2021
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6IUP
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![BU of 6iup by Molmil](/molmil-images/mine/6iup) | Crystal structure of FGFR4 kinase domain in complex with compound 5 | 分子名称: | DIMETHYL SULFOXIDE, Fibroblast growth factor receptor 4, N-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide | 著者 | Xu, Y, Liu, Q. | 登録日 | 2018-11-29 | 公開日 | 2019-11-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. J.Med.Chem., 62, 2019
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6J5S
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6J53
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![BU of 6j53 by Molmil](/molmil-images/mine/6j53) | |
6J58
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![BU of 6j58 by Molmil](/molmil-images/mine/6j58) | |
6J64
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![BU of 6j64 by Molmil](/molmil-images/mine/6j64) | Crystal structure of human HINT1 mutant complexing with AP4A | 分子名称: | 2-AMINOETHANESULFONIC ACID, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Histidine triad nucleotide-binding protein 1 | 著者 | Wang, J, Fang, P, Guo, M. | 登録日 | 2019-01-14 | 公開日 | 2019-09-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells. Nat Commun, 10, 2019
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4RHZ
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![BU of 4rhz by Molmil](/molmil-images/mine/4rhz) | Crystal structure of Cry23Aa1 and Cry37Aa1 binary protein complex | 分子名称: | CALCIUM ION, Cry23AA1, Cry37AA1, ... | 著者 | Rydel, T.J, Williams, J.M, Brown, G.R, Guzov, V.M, Sturman, E.J, Evdokimov, A. | 登録日 | 2014-10-03 | 公開日 | 2015-10-28 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The Associated Bacillus thuringiensis Binary Protein Complex of Cry23Aa1 and Cry37Aa1: Crystal Structure, Insecticidal Data, and Pore Formation Modeling. To be Published
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6IUO
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![BU of 6iuo by Molmil](/molmil-images/mine/6iuo) | Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor | 分子名称: | Fibroblast growth factor receptor 4, N-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide | 著者 | Xu, Y, Liu, Q. | 登録日 | 2018-11-29 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. J.Med.Chem., 62, 2019
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6ITJ
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![BU of 6itj by Molmil](/molmil-images/mine/6itj) | Crystal structure of FGFR1 kinase domain in complex with compound 3 | 分子名称: | 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{H}-pyrazolo[3,4-d]pyridazin-7-one, Fibroblast growth factor receptor 1 | 著者 | Xu, Y, Liu, Q. | 登録日 | 2018-11-23 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.994 Å) | 主引用文献 | Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. J.Med.Chem., 62, 2019
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2OUV
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![BU of 2ouv by Molmil](/molmil-images/mine/2ouv) | crystal structure of pde10a2 mutant of D564N | 分子名称: | MAGNESIUM ION, ZINC ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | 登録日 | 2007-02-12 | 公開日 | 2007-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2OUY
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![BU of 2ouy by Molmil](/molmil-images/mine/2ouy) | crystal structure of pde10a2 mutant D564A in complex with cAMP. | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MAGNESIUM ION, ZINC ION, ... | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | 登録日 | 2007-02-12 | 公開日 | 2007-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2OUP
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![BU of 2oup by Molmil](/molmil-images/mine/2oup) | crystal structure of PDE10A | 分子名称: | MAGNESIUM ION, ZINC ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | 登録日 | 2007-02-12 | 公開日 | 2007-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa, 104, 2007
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