1NOQ
| e-motif structure | 分子名称: | 5'-D(*CP*CP*GP*CP*CP*G)-3' | 著者 | Zheng, M, Huang, X, Smith, G.K, Yang, X, Gao, X. | 登録日 | 2003-01-16 | 公開日 | 2003-02-11 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding.
An NMR and UV spectroscopic study. J.Mol.Biol., 264, 1996
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1NP5
| (GAC)3 parallel duplex | 分子名称: | 5'-D(*GP*AP*CP*GP*AP*CP*GP*AP*C)-3' | 著者 | Zheng, M, Han, X, Gao, X. | 登録日 | 2003-01-17 | 公開日 | 2003-02-11 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Strand polarity of trinucleotide repeat sequences:
NMR studies of parallel/anti-pararell duplex,{d(GAC)3}2 To be Published
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3FMS
| Crystal structure of TM0439, a GntR transcriptional regulator | 分子名称: | ACETATE ION, NICKEL (II) ION, Transcriptional regulator, ... | 著者 | Zheng, M, Cooper, D.R, Yu, M, Hung, L.-W, Derewenda, U, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI) | 登録日 | 2008-12-22 | 公開日 | 2009-02-10 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains. Acta Crystallogr.,Sect.D, 65, 2009
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6V1V
| VIP3B (VIP3B_2160) adapted for crystallization | 分子名称: | Vegetative insecticidal protein | 著者 | Evdokimov, A.G, Zheng, M, Moshiri, F, Haas, J, Lowder, C. | 登録日 | 2019-11-21 | 公開日 | 2019-12-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.189 Å) | 主引用文献 | Crystal structure of a Vip3B family insecticidal protein reveals a new fold and a unique tetrameric assembly. Protein Sci., 29, 2020
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3QOR
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4W8J
| Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals | 分子名称: | CALCIUM ION, POTASSIUM ION, Pesticidal crystal protein cry1Ac | 著者 | Evdokimov, A.G, Moshiri, F, Sturman, E.J, Rydel, T.J, Zheng, M, Seale, J.W, Franklin, S. | 登録日 | 2014-08-25 | 公開日 | 2014-09-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals. Protein Sci., 23, 2014
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7ML9
| The Mpp75Aa1.1 beta-pore-forming protein from Brevibacillus laterosporus | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Insecticidal protein, ... | 著者 | Rydel, T.J, Zheng, M, Evdokimov, A. | 登録日 | 2021-04-27 | 公開日 | 2021-05-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural and functional characterization of Mpp75Aa1.1, a putative beta-pore forming protein from Brevibacillus laterosporus active against the western corn rootworm. Plos One, 16, 2021
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7MJR
| Vip4Da2 toxin structure | 分子名称: | CALCIUM ION, SULFATE ION, Vip4Da1 protein | 著者 | Rydel, T.J, Duda, D, Zheng, M, Henry, A. | 登録日 | 2021-04-20 | 公開日 | 2021-05-05 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Structural and functional insights into the first Bacillus thuringiensis vegetative insecticidal protein of the Vpb4 fold, active against western corn rootworm. Plos One, 16, 2021
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1WPB
| Structure of Escherichia coli yfbU gene product | 分子名称: | CHLORIDE ION, GLYCEROL, hypothetical protein yfbU | 著者 | Borek, D, Chen, Y, Zheng, M, Skarina, T, Savchenko, A, Edwards, A, Otwinowski, Z, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2004-09-01 | 公開日 | 2004-12-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of Escherichia coli yfbU gene product To be Published
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2A7R
| Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2) | 分子名称: | GMP reductase 2, GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION | 著者 | Li, J, Wei, Z, Zheng, M, Gu, X, Deng, Y, Qiu, R, Chen, F, Ji, C, Gong, W, Xie, Y, Mao, Y. | 登録日 | 2005-07-05 | 公開日 | 2006-01-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structure of Human Guanosine Monophosphate Reductase 2 (GMPR2) in Complex with GMP J.Mol.Biol., 355, 2006
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6D0O
| rdpA dioxygenase holoenzyme | 分子名称: | (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase, 2-OXOGLUTARIC ACID, COBALT (II) ION | 著者 | Rydel, T.J, Sturman, E.J, Zheng, M, Evdokimov, A. | 登録日 | 2018-04-10 | 公開日 | 2018-08-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Development of enzymes for robust aryloxyphenoxypropionate and synthetic auxin herbicide tolerance traits in maize and soybean crops. Pest Manag. Sci., 75, 2019
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5ZYQ
| The Structure of Human PAF1/CTR9 complex | 分子名称: | RNA polymerase-associated protein CTR9 homolog,RNA polymerase II-associated factor 1 homolog | 著者 | Xie, Y, Zheng, M, Zhou, H, Long, J. | 登録日 | 2018-05-28 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.531 Å) | 主引用文献 | Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation. Nat Commun, 9, 2018
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5ZYP
| Structure of the Yeast Ctr9/Paf1 complex | 分子名称: | NICKEL (II) ION, RNA polymerase-associated protein CTR9,RNA polymerase II-associated protein 1 | 著者 | Xie, Y, Zheng, M, Zhou, H, Long, J. | 登録日 | 2018-05-28 | 公開日 | 2018-09-26 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (2.532 Å) | 主引用文献 | Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation. Nat Commun, 9, 2018
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6LN1
| A natural inhibitor of DYRK1A for treatment of diabetes mellitus | 分子名称: | 1,3,5,8-tetrakis(oxidanyl)xanthen-9-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 著者 | Li, H, Chen, L.X, Zheng, M.Z, Zhang, Q.Z, Zhang, C.L, Wu, C.R, Yang, K.Y, Song, Z.R, Wang, Q.Q, Li, C, Zhou, Y.R, Chen, J.C. | 登録日 | 2019-12-28 | 公開日 | 2021-10-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.699 Å) | 主引用文献 | A natural DYRK1A inhibitor as a potential stimulator for beta-cell proliferation in diabetes. Clin Transl Med, 11, 2021
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8HLT
| The co-crystal structure of DYRK2 with YK-2-99B | 分子名称: | (6-{[(4P)-4-(1,3-benzothiazol-5-yl)-5-fluoropyrimidin-2-yl]amino}pyridin-3-yl)(piperazin-1-yl)methanone, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | 著者 | Shen, H.T, Xiao, Y.B, Yuan, K, Yang, P, Li, Q.N. | 登録日 | 2022-12-01 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer. J.Med.Chem., 66, 2023
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7E6V
| The crystal structure of foot-and-mouth disease virus(FMDV) 2C protein 97-318aa | 分子名称: | ACETATE ION, Protein 2C | 著者 | Zhang, C, Wojdyla, J.A, Qin, B, Wang, M, Gao, X, Cui, S. | 登録日 | 2021-02-24 | 公開日 | 2022-06-29 | 最終更新日 | 2022-07-20 | 実験手法 | X-RAY DIFFRACTION (1.832 Å) | 主引用文献 | An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein. Cell Rep, 40, 2022
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6AFR
| Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol | 分子名称: | 5-[(4-fluoranylimidazol-1-yl)methyl]quinolin-8-ol, Bromodomain-containing protein 4 | 著者 | Xing, J, Zhang, R.K, Zheng, M.Y, Luo, C, Jiang, X.R. | 登録日 | 2018-08-08 | 公開日 | 2018-12-12 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors Eur J Med Chem, 163, 2018
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4G2W
| Crystal structure of PDE5A in complex with its inhibitor | 分子名称: | 5,6-diethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | 著者 | Ren, J, Chen, T.T, Xu, Y.C. | 登録日 | 2012-07-13 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. J.Med.Chem., 55, 2012
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4G2Y
| Crystal structure of PDE5A complexed with its inhibitor | 分子名称: | 2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | 著者 | Ren, J, Chen, T.T, Xu, Y.C. | 登録日 | 2012-07-13 | 公開日 | 2013-06-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. J.Med.Chem., 55, 2012
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6ITJ
| Crystal structure of FGFR1 kinase domain in complex with compound 3 | 分子名称: | 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{H}-pyrazolo[3,4-d]pyridazin-7-one, Fibroblast growth factor receptor 1 | 著者 | Xu, Y, Liu, Q. | 登録日 | 2018-11-23 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.994 Å) | 主引用文献 | Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. J.Med.Chem., 62, 2019
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6D3J
| FT_T dioxygenase holoenzyme | 分子名称: | 2-OXOGLUTARIC ACID, COBALT (II) ION, FT_T dioxygenase | 著者 | Rydel, T.J, Halls, C.E. | 登録日 | 2018-04-16 | 公開日 | 2018-08-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Development of enzymes for robust aryloxyphenoxypropionate and synthetic auxin herbicide tolerance traits in maize and soybean crops. Pest Manag. Sci., 75, 2019
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6D1O
| FT_5 dioxygenase apoenzyme | 分子名称: | (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase | 著者 | Rydel, T.J, Halls, C.E. | 登録日 | 2018-04-12 | 公開日 | 2018-08-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Development of enzymes for robust aryloxyphenoxypropionate and synthetic auxin herbicide tolerance traits in maize and soybean crops. Pest Manag. Sci., 75, 2019
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6D3M
| FT_T dioxygenase with bound quizalofop | 分子名称: | (2R)-2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoic acid, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | 著者 | Rydel, T.J, Halls, C.E. | 登録日 | 2018-04-16 | 公開日 | 2018-08-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Development of enzymes for robust aryloxyphenoxypropionate and synthetic auxin herbicide tolerance traits in maize and soybean crops. Pest Manag. Sci., 75, 2019
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6D3I
| ftv7 dioxygenase with 2,4-D bound | 分子名称: | (2,4-DICHLOROPHENOXY)ACETIC ACID, 2-OXOGLUTARIC ACID, COBALT (II) ION, ... | 著者 | Rydel, T.J, Halls, C.E. | 登録日 | 2018-04-16 | 公開日 | 2018-08-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.196 Å) | 主引用文献 | Development of enzymes for robust aryloxyphenoxypropionate and synthetic auxin herbicide tolerance traits in maize and soybean crops. Pest Manag. Sci., 75, 2019
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6D3H
| FT_T dioxygenase with bound dichlorprop | 分子名称: | (2R)-2-(2,4-dichlorophenoxy)propanoic acid, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | 著者 | Rydel, T.J, Halls, C.E. | 登録日 | 2018-04-16 | 公開日 | 2018-08-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Development of enzymes for robust aryloxyphenoxypropionate and synthetic auxin herbicide tolerance traits in maize and soybean crops. Pest Manag. Sci., 75, 2019
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