6J5S

Crystal structure of human HINT1 mutant complexing with AP5A

Summary for 6J5S

• Entry DOI: 10.2210/pdb6j5s/pdb
• Related: 5ED3 5ED6 6J53 6J58
• Descriptor: Histidine triad nucleotide-binding protein 1, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: hydrolase, nucleotide binding, regulation of transcription, signal transduction
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 28940.69

Authors

Wang, J.,Fang, P.,Guo, M. (deposition date: 2019-01-11, release date: 2019-09-25, Last modification date: 2023-11-22)

• Primary citation: Yu, J.,Liu, Z.,Liang, Y.,Luo, F.,Zhang, J.,Tian, C.,Motzik, A.,Zheng, M.,Kang, J.,Zhong, G.,Liu, C.,Fang, P.,Guo, M.,Razin, E.,Wang, J.; Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells.; Nat Commun, 10:4664-4664, 2019; PubMed: 31604935; DOI: 10.1038/s41467-019-12710-8

Experimental method

X-RAY DIFFRACTION (1.02 Å)