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6J5S

Crystal structure of human HINT1 mutant complexing with AP5A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0005080molecular_functionprotein kinase C binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006351biological_processDNA-templated transcription
A0006355biological_processregulation of DNA-templated transcription
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0007165biological_processsignal transduction
A0008233molecular_functionpeptidase activity
A0008234molecular_functioncysteine-type peptidase activity
A0009154biological_processpurine ribonucleotide catabolic process
A0016787molecular_functionhydrolase activity
A0016926biological_processprotein desumoylation
A0016929molecular_functiondeSUMOylase activity
A0043530molecular_functionadenosine 5'-monophosphoramidase activity
A0050850biological_processpositive regulation of calcium-mediated signaling
A0070062cellular_componentextracellular exosome
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0000118cellular_componenthistone deacetylase complex
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0005080molecular_functionprotein kinase C binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006351biological_processDNA-templated transcription
B0006355biological_processregulation of DNA-templated transcription
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0007165biological_processsignal transduction
B0008233molecular_functionpeptidase activity
B0008234molecular_functioncysteine-type peptidase activity
B0009154biological_processpurine ribonucleotide catabolic process
B0016787molecular_functionhydrolase activity
B0016926biological_processprotein desumoylation
B0016929molecular_functiondeSUMOylase activity
B0043530molecular_functionadenosine 5'-monophosphoramidase activity
B0050850biological_processpositive regulation of calcium-mediated signaling
B0070062cellular_componentextracellular exosome
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
Functional Information from PDB Data
site_idAC1
Number of Residues43
Detailsbinding site for residue AP5 B 201
ChainResidue
BILE18
BILE44
BSER45
BLEU53
BGLY105
BGLN106
BSER107
BVAL108
BHIS112
BHOH302
BHOH303
BILE18
BHOH306
BHOH307
BHOH311
BHOH316
BHOH316
BHOH328
BHOH352
BHOH365
BHOH378
BHOH382
BPHE19
BHOH392
BHOH397
BHOH397
BHOH402
BHOH403
BHOH403
BHOH413
BHOH414
BHOH415
BHOH415
BPRO28
BHOH418
BHOH432
BHOH439
BHOH511
BPHE41
BHIS42
BHIS42
BASP43
BILE44

site_idAC2
Number of Residues8
Detailsbinding site for residue ESA B 202
ChainResidue
BTHR17
BTHR17
BILE18
BILE18
BVAL108
BHOH375
BHOH375
BHOH392

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues216
DetailsDomain: {"description":"HIT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsMotif: {"description":"Histidine triad motif"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsActive site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"PubMed","id":"9323207","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22869114","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TW2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P70349","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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