3GYW
| Crystal structure of nucleosome assembly protein from Plasmodium falciparum at 2.4 A resolution | 分子名称: | Nucleosome assembly protein 1, putative | 著者 | Yogavel, M, Gill, J, Sharma, A. | 登録日 | 2009-04-06 | 公開日 | 2009-05-12 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Iodide-SAD, SIR and SIRAS phasing for structure solution of a nucleosome assembly protein. Acta Crystallogr.,Sect.D, 65, 2009
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3GYV
| Crystal structure of nucleosome assembly protein from Plasmodium falciparum | 分子名称: | IODIDE ION, Nucleosome assembly protein 1, putative | 著者 | Yogavel, M, Gill, J, Sharma, A. | 登録日 | 2009-04-06 | 公開日 | 2009-05-12 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Iodide-SAD, SIR and SIRAS phasing for structure solution of a nucleosome assembly protein. Acta Crystallogr.,Sect.D, 65, 2009
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4MZC
| Atomic Resolution Structure of PfGrx1 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Glutaredoxin | 著者 | Yogavel, M, Sharma, A. | 登録日 | 2013-09-30 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (0.949 Å) | 主引用文献 | Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins. Acta Crystallogr.,Sect.D, 70, 2014
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4N11
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4N0Z
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4MZB
| Crystal structure of Grx1 from Plasmodium falciparum | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Glutaredoxin | 著者 | Yogavel, M, Sharma, A. | 登録日 | 2013-09-30 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.038 Å) | 主引用文献 | Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins. Acta Crystallogr.,Sect.D, 70, 2014
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4N10
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7VC1
| Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L95 and L-proline in space group P21 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Yogavel, M, Malhotra, N, Sharma, A. | 登録日 | 2021-09-01 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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7VC2
| Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L96 and L-proline in space group P21 | 分子名称: | 1,2-ETHANEDIOL, 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, CHLORIDE ION, ... | 著者 | Yogavel, M, Malhotra, N, Sharma, A. | 登録日 | 2021-09-01 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.096 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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6AGT
| Crystal structure of PfKRS complexed with chromone inhibitor | 分子名称: | COBALT (II) ION, FORMIC ACID, LYSINE, ... | 著者 | Yogavel, M, Sharma, A, Sharma, A, Baragana, B, Walpole, C. | 登録日 | 2018-08-14 | 公開日 | 2019-03-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | 主引用文献 | Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7VC3
| Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L97 and L-proline at 1.97 A resolution | 分子名称: | 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, CHLORIDE ION, ETHANOLAMINE, ... | 著者 | Malhotra, N, Yogavel, M, Sharma, A. | 登録日 | 2021-09-01 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.973 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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7FAL
| Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T36 and L-pro | 分子名称: | 4-[(3R)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS) | 著者 | Malhotra, N, Mishra, S, Yogavel, M, Sharma, A. | 登録日 | 2021-07-06 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.219 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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7FAN
| Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T35 and L-pro | 分子名称: | 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS) | 著者 | Mishra, S, Malhotra, N, Yogavel, M, Sharma, A. | 登録日 | 2021-07-06 | 公開日 | 2022-09-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.769 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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7FAM
| Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with L97 and L-pro | 分子名称: | 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS) | 著者 | Mishra, S, Malhotra, N, Yogavel, M, Sharma, A. | 登録日 | 2021-07-06 | 公開日 | 2022-09-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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7FAK
| Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with L96 and L-pro | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ACETATE ION, ... | 著者 | Malhotra, N, Mishra, S, Yogavel, M, Sharma, A. | 登録日 | 2021-07-06 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
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4TWA
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4YDQ
| Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum in complex with Halofuginone and AMPPNP | 分子名称: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Jain, V, Yogavel, M, Sharma, A. | 登録日 | 2015-02-23 | 公開日 | 2015-05-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis Structure, 23, 2015
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2VWA
| Crystal structure of a sporozoite protein essential for liver stage development of malaria parasite | 分子名称: | PHOSPHATIDYLETHANOLAMINE, PUTATIVE UNCHARACTERIZED PROTEIN PF13_0012 | 著者 | Sharma, A, Sharma, A, Yogavel, M, Gill, J, Akhouri, R.R. | 登録日 | 2008-06-20 | 公開日 | 2008-07-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of Soluble Domain of Malaria Sporozoite Protein Uis3 in Complex with Lipid. J.Biol.Chem., 283, 2008
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4PG3
| Crystal structure of KRS complexed with inhibitor | 分子名称: | LYSINE, Lysine--tRNA ligase, cladosporin | 著者 | Sharma, A, Yogavel, M, Khan, S, Sharma, A, Belrhali, H. | 登録日 | 2014-05-01 | 公開日 | 2014-07-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.696 Å) | 主引用文献 | Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin. J. Struct. Funct. Genomics, 15, 2014
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6AA0
| Crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in Apo Form | 分子名称: | GLYCEROL, Prolyl-tRNA synthetase (ProRS) | 著者 | Mishra, S, Kumari, S, Sharma, A, Yogavel, M. | 登録日 | 2018-07-16 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Conformational heterogeneity in apo and drug-bound structures of Toxoplasma gondii prolyl-tRNA synthetase. Acta Crystallogr.,Sect.F, 75, 2019
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2IRP
| Crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979) from aquifex aeolicus VF5 | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Putative aldolase class 2 protein aq_1979 | 著者 | Jeyakanthan, J, Gayathri, D, Yogavel, M, Velmurugan, D, Baba, S, Ebihara, A, Kuramitsu, S, Shinkai, A, Shiro, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2006-10-16 | 公開日 | 2007-10-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979) from aquifex aeolicus VF5 To be Published
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2BAX
| Atomic Resolution Structure of the Double Mutant (K53,56M) of Bovine Pancreatic Phospholipase A2 | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ... | 著者 | Sekar, K, Yogavel, M, Velmurugan, D, Dauter, Z, Dauter, M, Tsai, M.D. | 登録日 | 2005-10-15 | 公開日 | 2005-10-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Atomic resolution (0.97 A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2. Acta Crystallogr.,Sect.F, 61, 2005
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6A88
| Crystal Structure of T. gondii prolyl tRNA synthetase with Febrifugine and ATP Analog | 分子名称: | 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Kumari, S, Mishra, S, Yogavel, M, Sharma, A. | 登録日 | 2018-07-06 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.596 Å) | 主引用文献 | Conformational heterogeneity in apo and drug-bound structures of Toxoplasma gondii prolyl-tRNA synthetase. Acta Crystallogr.,Sect.F, 75, 2019
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3FS3
| Crystal structure of malaria parasite Nucleosome Assembly Protein (NAP) | 分子名称: | Nucleosome assembly protein 1, putative | 著者 | Gill, J, Yogavel, M, Kumar, A, Belrhali, H, Sharma, A. | 登録日 | 2009-01-09 | 公開日 | 2009-01-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of malaria parasite nucleosome assembly protein: distinct modes of protein localization and histone recognition. J.Biol.Chem., 284, 2009
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5HGQ
| Loa loa Lysyl-tRNA synthetase in complex with Cladosporin. | 分子名称: | GLYCEROL, LYSINE, Lysine--tRNA ligase, ... | 著者 | Sharma, A, Sharma, M, Yogavel, M, Sharma, A. | 登録日 | 2016-01-08 | 公開日 | 2016-10-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.283 Å) | 主引用文献 | Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis PLoS Negl Trop Dis, 10, 2016
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