7FAM

Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with L97 and L-pro

Summary for 7FAM

Entry DOI	10.2210/pdb7fam/pdb
Descriptor	Prolyl-tRNA synthetase (ProRS), 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, ... (4 entities in total)
Functional Keywords	inhibitor-bound structural comparison, translation, multi-drug
Biological source	Toxoplasma gondii
Total number of polymer chains	1
Total formula weight	58529.92
Authors	Mishra, S.,Malhotra, N.,Yogavel, M.,Sharma, A. (deposition date: 2021-07-06, release date: 2022-09-28, Last modification date: 2023-11-29)
Primary citation	Yogavel, M.,Bougdour, A.,Mishra, S.,Malhotra, N.,Chhibber-Goel, J.,Bellini, V.,Harlos, K.,Laleu, B.,Hakimi, M.A.,Sharma, A. Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19:e1011124-e1011124, 2023 Cited by PubMed: 36854028 DOI: 10.1371/journal.ppat.1011124 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.42 Å)

Structure validation