7VC2

Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L96 and L-proline in space group P21

Summary for 7VC2

Entry DOI	10.2210/pdb7vc2/pdb
Descriptor	Prolyl-tRNA synthetase (ProRS), 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, ... (6 entities in total)
Functional Keywords	protein translation, inhibitor, prs, atp pocket, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Toxoplasma gondii
Total number of polymer chains	2
Total formula weight	117884.12
Authors	Yogavel, M.,Malhotra, N.,Sharma, A. (deposition date: 2021-09-01, release date: 2022-09-07, Last modification date: 2023-11-29)
Primary citation	Yogavel, M.,Bougdour, A.,Mishra, S.,Malhotra, N.,Chhibber-Goel, J.,Bellini, V.,Harlos, K.,Laleu, B.,Hakimi, M.A.,Sharma, A. Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19:e1011124-e1011124, 2023 Cited by PubMed: 36854028 DOI: 10.1371/journal.ppat.1011124 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.096 Å)

Structure validation