1D8M
 
 | | CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A HETEROCYCLE-BASED INHIBITOR | | 分子名称: | 1-BENZYL-3-(4-METHOXY-BENZENESULFONYL)-6-OXO-HEXAHYDRO-PYRIMIDINE-4-CARBOXYLIC ACID HYDROXYAMIDE, CALCIUM ION, STROMELYSIN-1 PRECURSOR, ... | | 著者 | Pikul, S, Dunham, K.M, Almstead, N.G, De, B, Natchus, M.G, Taiwo, Y.O, Williams, L.E, Hynd, B.A, Hsieh, L.C, Janusz, M.J, Gu, F, Mieling, G.E. | | 登録日 | 1999-10-25 | | 公開日 | 2000-10-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Heterocycle-based MMP inhibitors with P2' substituents.
Bioorg.Med.Chem.Lett., 11, 2001
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1G05
 | | HETEROCYCLE-BASED MMP INHIBITOR WITH P2'SUBSTITUENTS | | 分子名称: | 1-BENZYL-3-(4-METHOXY-BENZENESULFONYL)-6-OXO-HEXAHYDRO-PYRIMIDINE-4-CARBOXYLIC ACID HYDROXYAMIDE, CALCIUM ION, STROMELYSIN-1 PRECURSOR, ... | | 著者 | Pikul, S, Dunham, K.M, Almstead, N.G, De, B, Natchus, M.G, Taiwo, Y.O, Williams, L.E, Hynd, B.A, Hsieh, L.C, Janusz, M.J. | | 登録日 | 2000-10-05 | | 公開日 | 2001-10-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Heterocycle-based MMP inhibitors with P2' substituents.
Bioorg.Med.Chem.Lett., 11, 2001
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6XO4
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6XOB
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7V0N
 | | Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a moderately/weakly neutralizing human antibody IgG-21 | | 分子名称: | IgG 21 Fab heavy chain, IgG 21 Fab light chain, Spike glycoprotein E1, ... | | 著者 | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | | 登録日 | 2022-05-10 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | | 主引用文献 | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7V0O
 | | Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a moderately/weakly neutralizing human antibody IgG-94 | | 分子名称: | IgG 94 Fab heavy chain, IgG 94 Fab light chain, Spike glycoprotein E1, ... | | 著者 | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | | 登録日 | 2022-05-10 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7V0P
 | | Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a potently neutralizing human antibody IgG-106 | | 分子名称: | IgG 106 Fab heavy chain, IgG 106 Fab light chain, Spike glycoprotein E1, ... | | 著者 | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | | 登録日 | 2022-05-10 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | | 主引用文献 | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 120, 2023
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1D5J
 | | CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A THIAZEPINE BASED INHIBITOR. | | 分子名称: | CALCIUM ION, N-HYDROXY-4-[(4-METHOXYLPHENYL)SULFONYL]-2,2-DIMETHYL-HEXAHYDRO-1,4-THIAZEPINE-3(S)-CARBOXAMIDE, STROMELYSIN-1, ... | | 著者 | Almstead, N.G, Bradley, R.S, Pikul, S, De, B, Natchus, M.G. | | 登録日 | 1999-10-07 | | 公開日 | 2000-10-09 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors.
J.Med.Chem., 42, 1999
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1Q3A
 | | Crystal structure of the catalytic domain of human matrix metalloproteinase 10 | | 分子名称: | CALCIUM ION, N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID, Stromelysin-2, ... | | 著者 | Calderone, V, Bertini, I, Fragai, M, Luchinat, C, Mangani, S, Terni, B. | | 登録日 | 2003-07-29 | | 公開日 | 2004-04-06 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the catalytic domain of human matrix metalloproteinase 10.
J.Mol.Biol., 336, 2004
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5WEQ
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6WDT
 | | Enterovirus D68 in complex with human monoclonal antibody EV68-228 | | 分子名称: | EV68-228 heavy chain, EV68-228 light chain, viral protein 1, ... | | 著者 | Fu, J, Vogt, M.R, Klose, T, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-04-01 | | 公開日 | 2020-07-15 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
Sci Immunol, 5, 2020
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6WDS
 | | Enterovirus D68 in complex with human monoclonal antibody EV68-159 | | 分子名称: | EV68-159 heavy chain, EV68-159 light chain, viral protein 1, ... | | 著者 | Fu, J, Klose, T, Vogt, M.R, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-04-01 | | 公開日 | 2020-07-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
Sci Immunol, 5, 2020
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7SFU
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7SFW
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7SFV
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8EAY
 | | HMPV F complex with 4I3 Fab | | 分子名称: | 4I3 heavy chain protein, 4I3 light chain protein, Fusion glycoprotein F0 | | 著者 | Wen, X, Jardetzky, T.S. | | 登録日 | 2022-08-30 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode.
Cell Host Microbe, 31, 2023
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8E2U
 | | HMPV F monomer bound to RSV-199 Fab | | 分子名称: | Fusion glycoprotein F0, RSV-199 heavy chain, RSV-199 light chain | | 著者 | Wen, X, Jardetzky, T.S. | | 登録日 | 2022-08-16 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode.
Cell Host Microbe, 31, 2023
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8EBP
 | | HMPV F dimer bound to RSV-199 Fab | | 分子名称: | Fusion glycoprotein F0, RSV-199 heavy chain protein, RSV-199 light chain protein | | 著者 | Wen, X, Jardetzky, T.S. | | 登録日 | 2022-08-31 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode.
Cell Host Microbe, 31, 2023
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8DZW
 | | RSV F trimer bound to RSV-199 Fab | | 分子名称: | RSV fusion protein, RSV-199 Heavy chain protein, RSV-199 Light chain protein | | 著者 | Wen, X, Jardetzky, T.S. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | | 主引用文献 | Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode.
Cell Host Microbe, 31, 2023
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7KEW
 | | Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-43 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BDBV-43 Fab heavy chain, ... | | 著者 | Murin, C.D, Ward, A.B. | | 登録日 | 2020-10-13 | | 公開日 | 2021-04-28 | | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | | 主引用文献 | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
Cell Rep, 35, 2021
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7KFG
 | | Antibody Fab BDBV-289 | | 分子名称: | Antibody Fab BDBV-289 heavy chain, Antibody Fab BDBV-289 light chain, DI(HYDROXYETHYL)ETHER | | 著者 | Murin, C.D, Bruhn, J.F, Ward, A.B. | | 登録日 | 2020-10-13 | | 公開日 | 2021-04-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.002 Å) | | 主引用文献 | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
Cell Rep, 35, 2021
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7KFE
 | | Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-329 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody BDBV-329 heavy chain, ... | | 著者 | Murin, C.D, Ward, A.B. | | 登録日 | 2020-10-13 | | 公開日 | 2021-04-28 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
Cell Rep, 35, 2021
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7KFH
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7KFB
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7KEX
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