6FI9
 
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1JNE
 | | Crystal structure of imaginal disc growth factor-2 | | 分子名称: | Imaginal disc growth factor-2, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Varela, P.F, Llera, A.S, Mariuzza, R.A, Tormo, J. | | 登録日 | 2001-07-23 | | 公開日 | 2002-05-01 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster.
J.Biol.Chem., 277, 2002
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1JND
 | | Crystal structure of imaginal disc growth factor-2 | | 分子名称: | Imaginal disc growth factor-2, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Varela, P.F, Llera, A.S, Mariuzza, R.A, Tormo, J. | | 登録日 | 2001-07-23 | | 公開日 | 2002-05-01 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster.
J.Biol.Chem., 277, 2002
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1QMJ
 | | CG-16, a homodimeric agglutinin from chicken liver | | 分子名称: | BETA-GALACTOSIDE-BINDING LECTIN, BETA-MERCAPTOETHANOL | | 著者 | Varela, P.F, Solis, D, Diaz-Maurino, T, Kaltner, H, Gabius, H.-J, Romero, A. | | 登録日 | 1999-09-29 | | 公開日 | 2000-02-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | The 2.15 A Crystal Structure of Cg-16, the Developmentally Regulated Homodimeric Chicken Galectin
J.Mol.Biol., 294, 1999
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8CGZ
 | | tubulin-AB8939 complex | | 分子名称: | 1-[4-[2-[[5-(ethoxymethyl)-2-methyl-phenyl]amino]-1,3-oxazol-5-yl]phenyl]imidazolidin-2-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Varela, P.F, Gigant, B. | | 登録日 | 2023-02-06 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.527 Å) | | 主引用文献 | Development of AB8939, a Novel Colchicine-like Microtubule Synthetic Destabilizer with the Ability to Overcome Multidrug Resistance
TO BE PUBLISHED
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6H35
 | | Myxococcus xanthus MglA bound to GDP and Pi with mixed inactive and active switch region conformations | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Mutual gliding-motility protein MglA, ... | | 著者 | Varela, P.F, Galicia, C, Cherfils, J. | | 登録日 | 2018-07-17 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus.
Nat Commun, 10, 2019
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6HJO
 | | Myxococcus xanthus MglA bound to GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Mutual gliding-motility protein MglA | | 著者 | Varela, P.F, Cherfils, J. | | 登録日 | 2018-09-04 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus.
Nat Commun, 10, 2019
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6HJH
 | | Myxococcus xanthus MglA bound to GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Mutual gliding-motility protein MglA | | 著者 | Varela, P.F, Cherfils, J. | | 登録日 | 2018-09-03 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus.
Nat Commun, 10, 2019
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6HJM
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6H9B
 | | 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation | | 分子名称: | 9-methyl-3-[1-(2-methylquinolin-4-yl)ethenyl]carbazole, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Varela, P.F, Gigant, B. | | 登録日 | 2018-08-03 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.
J. Med. Chem., 62, 2019
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6TDE
 | | Tubulin-inhibitor complex | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Varela, P.F, Gigant, B. | | 登録日 | 2019-11-08 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.286 Å) | | 主引用文献 | Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicity.
Eur.J.Med.Chem., 207, 2020
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7Z6O
 | | X-Ray studies of Ku70/80 reveal the binding site for IP6 | | 分子名称: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Varela, P.F, Charbonnier, J.B. | | 登録日 | 2022-03-14 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
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1Y4M
 | | Crystal structure of human endogenous retrovirus HERV-FRD envelope protein (syncitin-2) | | 分子名称: | CHLORIDE ION, HERV-FRD_6p24.1 provirus ancestral Env polyprotein | | 著者 | Renard, M, Varela, P.F, Letzelter, C, Duquerroy, S, Rey, F.A, Heidmann, T. | | 登録日 | 2004-12-01 | | 公開日 | 2005-11-15 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates.
J.Mol.Biol., 352, 2005
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2WJ8
 | | Respiratory Syncitial Virus RiboNucleoProtein | | 分子名称: | BORATE ION, NUCLEOPROTEIN, RNA (5'-R(*CP*CP*CP*CP*CP*C)-3') | | 著者 | Tawar, R.G, Duquerroy, S, Vonrhein, C, Varela, P.F, Damier-Piolle, L, Castagne, N, MacLellan, K, Bedouelle, H, Bricogne, G, Bhella, D, Eleouet, J, Rey, F.A. | | 登録日 | 2009-05-25 | | 公開日 | 2009-12-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus
Science, 326, 2009
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1SPP
 | | THE CRYSTAL STRUCTURES OF TWO MEMBERS OF THE SPERMADHESIN FAMILY REVEAL THE FOLDING OF THE CUB DOMAIN | | 分子名称: | MAJOR SEMINAL PLASMA GLYCOPROTEIN PSP-I, MAJOR SEMINAL PLASMA GLYCOPROTEIN PSP-II | | 著者 | Romero, A, Romao, M.J, Varela, P.F, Kolln, I, Dias, J.M, Carvalho, A.L, Sanz, L, Topfer-Petersen, E, Calvete, J.J. | | 登録日 | 1997-06-19 | | 公開日 | 1998-06-24 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The crystal structures of two spermadhesins reveal the CUB domain fold.
Nat.Struct.Biol., 4, 1997
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1PCS
 | | THE 2.15 A CRYSTAL STRUCTURE OF A TRIPLE MUTANT PLASTOCYANIN FROM THE CYANOBACTERIUM SYNECHOCYSTIS SP. PCC 6803 | | 分子名称: | COPPER (II) ION, PLASTOCYANIN | | 著者 | Romero, A, De La Cerda, B, Varela, P.F, Navarro, J.A, Hervas, M, De La Rosa, M.A. | | 登録日 | 1997-06-17 | | 公開日 | 1997-12-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | The 2.15 A crystal structure of a triple mutant plastocyanin from the cyanobacterium Synechocystis sp. PCC 6803.
J.Mol.Biol., 275, 1998
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1SFP
 | | CRYSTAL STRUCTURE OF ACIDIC SEMINAL FLUID PROTEIN (ASFP) AT 1.9 A RESOLUTION: A BOVINE POLYPEPTIDE FROM THE SPERMADHESIN FAMILY | | 分子名称: | ASFP | | 著者 | Romao, M.J, Kolln, I, Dias, J.M, Carvalho, A.L, Romero, A, Varela, P.F, Sanz, L, Topfer-Petersen, E, Calvete, J.J. | | 登録日 | 1997-06-24 | | 公開日 | 1998-06-24 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structures of two spermadhesins reveal the CUB domain fold.
Nat.Struct.Biol., 4, 1997
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7A40
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7A5E
 | | OSM-3 kinesin motor domain complexed with Mg.AMPPNP | | 分子名称: | GLYCEROL, MAGNESIUM ION, Osmotic avoidance abnormal protein 3, ... | | 著者 | Varela, F.P, Menetrey, J, Gigant, B. | | 登録日 | 2020-08-21 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | | 主引用文献 | Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism.
Febs Open Bio, 11, 2021
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7A3Z
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6TH4
 | | Tubulin-inhibitor complex | | 分子名称: | 1,2,3,9-tetramethoxy-6-methylidene-5~{H}-cyclohepta[a]naphthalen-8-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Varela, P.F, Gigant, B. | | 登録日 | 2019-11-18 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.121 Å) | | 主引用文献 | B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner
Acs Omega, 7, 2022
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5OJ8
 | | Crystal structure of the KLC1-TPR domain ([A1-B5] fragment) | | 分子名称: | Kinesin light chain 1, PHOSPHATE ION | | 著者 | Nguyen, T.Q, Chenon, M, Vilela, F, Velours, C, Fernandez-Varela, P, Llinas, P, Menetrey, J. | | 登録日 | 2017-07-20 | | 公開日 | 2017-10-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.247 Å) | | 主引用文献 | Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
PLoS ONE, 12, 2017
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5OJF
 | | Crystal Structure of KLC2-TPR domain (fragment [A1-B6] | | 分子名称: | Kinesin light chain 2 | | 著者 | Nguyen, T.Q, Chenon, M, Vilela, F, Velours, C, Andreani, J, Fernandez-Varela, P, Llinas, P, Menetrey, J. | | 登録日 | 2017-07-21 | | 公開日 | 2017-10-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
PLoS ONE, 12, 2017
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6H17
 | | Myxococcus xanthus MglA bound to GTPgammaS | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Mutual gliding-motility protein MglA, ... | | 著者 | Galicia, C, Cherfils, J. | | 登録日 | 2018-07-11 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.275 Å) | | 主引用文献 | MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus.
Nat Commun, 10, 2019
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6H5B
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