6H9B
1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation
Summary for 6H9B
Entry DOI | 10.2210/pdb6h9b/pdb |
Descriptor | Tubulin alpha chain, Tubulin beta chain, Stathmin-4, ... (9 entities in total) |
Functional Keywords | cytoskeleton, cell division, intracellular transport, transport protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 5 |
Total formula weight | 214031.09 |
Authors | Varela, P.F.,Gigant, B. (deposition date: 2018-08-03, release date: 2018-12-19, Last modification date: 2024-01-17) |
Primary citation | Naret, T.,Khelifi, I.,Provot, O.,Bignon, J.,Levaique, H.,Dubois, J.,Souce, M.,Kasselouri, A.,Deroussent, A.,Paci, A.,Varela, P.F.,Gigant, B.,Alami, M.,Hamze, A. 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. J. Med. Chem., 62:1902-1916, 2019 Cited by PubMed: 30525602DOI: 10.1021/acs.jmedchem.8b01386 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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