8CGZ
tubulin-AB8939 complex
Summary for 8CGZ
Entry DOI | 10.2210/pdb8cgz/pdb |
Descriptor | Tubulin alpha chain, Tubulin beta chain, Stathmin-4, ... (9 entities in total) |
Functional Keywords | microtubule dynamics, inhibitor, cytoskeleton, cell division, cell cycle |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 5 |
Total formula weight | 220209.10 |
Authors | |
Primary citation | Humbert, M.,Letard, S.,Neves, M.,Siavoshian Jeay, S.,Goubard, A.,Casteran, N.,Rebuffet, E.,Hajem, B.,Gros, L.,Varela, P.F.,Gigant, B.,Verdier, P.,Castellano, R.,Colette, Y.,Vey, N.,Pez, D.,Benjahad, A.,Moussy, A.,Mansfield, C.,Dubreuil, P. Development of AB8939, a Novel Colchicine-like Microtubule Synthetic Destabilizer with the Ability to Overcome Multidrug Resistance TO BE PUBLISHED, |
Experimental method | X-RAY DIFFRACTION (2.527 Å) |
Structure validation
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