1II6
 
 | | Crystal Structure of the Mitotic Kinesin Eg5 in Complex with Mg-ADP. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-RELATED MOTOR PROTEIN Eg5, MAGNESIUM ION, ... | | 著者 | Turner, J, Anderson, R, Guo, J, Beraud, C, Sakowicz, R, Fletterick, R. | | 登録日 | 2001-04-20 | | 公開日 | 2001-07-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
J.Biol.Chem., 276, 2001
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6NP6
 | | Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis | | 分子名称: | Crp/Fnr family transcriptional regulator, GLYCEROL | | 著者 | Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Scarsdale, J.N, Lewis, J.P. | | 登録日 | 2019-01-17 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Nitrosative Stress Sensing in Porphyromonas gingivalis: Structure and Mechanisms of the Heme Binding Transcriptional Regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019
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2W3L
 | | Crystal Structure of Chimaeric Bcl2-xL and Phenyl Tetrahydroisoquinoline Amide Complex | | 分子名称: | 1-(2-{[(3S)-3-(aminomethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-4-chloro-5-methyl-N,N-diphenyl-1H-pyrazole-3-carboxamide, APOPTOSIS REGULATOR BCL-2 | | 著者 | Porter, J, Payne, A, de Candole, B, Ford, D, Hutchinson, B, Trevitt, G, Turner, J, Edwards, C, Watkins, C, Whitcombe, I, Davis, J, Stubberfield, C, Fisher, M, Lamers, M. | | 登録日 | 2008-11-13 | | 公開日 | 2008-12-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Tetrahydroisoquinoline Amide Substituted Phenyl Pyrazoles as Selective Bcl-2 Inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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1RY6
 | | Crystal Structure of Internal Kinesin Motor Domain | | 分子名称: | INTERNAL KINESIN, SULFATE ION | | 著者 | Shipley, K, Hekmat-Nejad, M, Turner, J, Moores, C, Anderson, R, Milligan, R, Sakowicz, R, Fletterick, R. | | 登録日 | 2003-12-19 | | 公開日 | 2004-04-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of a kinesin microtubule depolymerization machine.
Embo J., 23, 2004
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2VSC
 | | Structure of the immunoglobulin-superfamily ectodomain of human CD47 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LEUKOCYTE SURFACE ANTIGEN CD47, MAGNESIUM ION | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-12 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
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1CZD
 | | CRYSTAL STRUCTURE OF THE PROCESSIVITY CLAMP GP45 FROM BACTERIOPHAGE T4 | | 分子名称: | DNA POLYMERASE ACCESSORY PROTEIN G45 | | 著者 | Moarefi, I, Jeruzalmi, D, Turner, J, O'Donnell, M, Kuriyan, J. | | 登録日 | 1999-09-02 | | 公開日 | 2000-03-03 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage.
J.Mol.Biol., 296, 2000
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2JES
 | | Portal protein (gp6) from bacteriophage SPP1 | | 分子名称: | CALCIUM ION, MERCURY (II) ION, PORTAL PROTEIN, ... | | 著者 | Lebedev, A.A, Krause, M.H, Isidro, A.L, Vagin, A.A, Orlova, E.V, Turner, J, Dodson, E.J, Tavares, P, Antson, A.A. | | 登録日 | 2007-01-21 | | 公開日 | 2007-03-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural Framework for DNA Translocation Via the Viral Portal Protein
Embo J., 26, 2007
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2JJT
 | | Structure of human CD47 in complex with human signal regulatory protein (SIRP) alpha | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LEUKOCYTE SURFACE ANTIGEN CD47, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1 | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Mol. Cell, 31, 2008
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2JJV
 | | Structure of human signal regulatory protein (sirp) beta(2) | | 分子名称: | CHLORIDE ION, SIGNAL-REGULATORY PROTEIN BETA 1., SULFATE ION | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
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2JJS
 | | Structure of human CD47 in complex with human signal regulatory protein (SIRP) alpha | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IODIDE ION, LEUKOCYTE SURFACE ANTIGEN CD47, ... | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Mol. Cell, 31, 2008
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2JJU
 | | Structure of human signal regulatory protein (sirp) beta | | 分子名称: | CHLORIDE ION, SIGNAL REGULATORY PROTEIN BETA-1, SULFATE ION | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
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2JJW
 | | Structure of human signal regulatory protein (sirp) gamma | | 分子名称: | SIGNAL REGULATORY PROTEIN GAMMA | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
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2QU2
 | | BACE1 with Compound 1 | | 分子名称: | Beta-secretase 1, N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide | | 著者 | Chopra, R. | | 登録日 | 2007-08-03 | | 公開日 | 2008-08-05 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Thiophene substituted acylguanidines as BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
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6C6M
 | | IgCam3 of human MLCK1 | | 分子名称: | Myosin light chain kinase, smooth muscle | | 著者 | Zuccola, H.J, Turner, J. | | 登録日 | 2018-01-19 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis.
Nat. Med., 25, 2019
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6ZCI
 | | Crystal structure of BRD4-BD1 in complex with NVS-BET-1 | | 分子名称: | (4~{R})-4-(4-chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6-oxidanylidene-pyridin-3-yl)-3-methyl-4~{H}-pyrrolo[3,4-c]pyrazol-6-one, Bromodomain-containing protein 4 | | 著者 | Faller, M. | | 登録日 | 2020-06-11 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.976 Å) | | 主引用文献 | BET bromodomain inhibitors regulate keratinocyte plasticity.
Nat.Chem.Biol., 17, 2021
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4DG6
 | | Crystal structure of domains 1 and 2 of LRP6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Low-density lipoprotein receptor-related protein 6, PHOSPHATE ION | | 著者 | Ceska, T.A, Doyle, C, Slocombe, P. | | 登録日 | 2012-01-25 | | 公開日 | 2012-06-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Characterization of the interaction of sclerostin with the LRP family of Wnt co-receptors
To be Published
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6M8Q
 | | Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in complex with NVP-LTM531 | | 分子名称: | Cleavage and polyadenylation specificity factor subunit 3, N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzene-1-carbonyl}-L-phenylalanine, PHOSPHATE ION, ... | | 著者 | Weihofen, W.A, Salcius, M, Michaud, G. | | 登録日 | 2018-08-22 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
Nat.Chem.Biol., 16, 2020
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3S7L
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3S7M
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6VBC
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6VBM
 | | Crystal structure of a S310A mutant of PBP2 from Neisseria gonorrhoeae | | 分子名称: | PHOSPHATE ION, Probable peptidoglycan D,D-transpeptidase PenA | | 著者 | Singh, A, Davies, C. | | 登録日 | 2019-12-19 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Mutations in Neisseria gonorrhoeae penicillin-binding protein 2 associated with extended-spectrum cephalosporin resistance create an energetic barrier against acylation via restriction of protein dynamics
J.Biol.Chem., 2020
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6VBD
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6VBL
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3OOZ
 | | Bace1 in complex with the aminohydantoin Compound 102 | | 分子名称: | (5R)-2-amino-5-[4-(difluoromethoxy)phenyl]-5-[4-fluoro-3-(5-fluoropent-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, Beta-secretase 1 | | 著者 | Olland, A.M. | | 登録日 | 2010-08-31 | | 公開日 | 2011-08-31 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Design and Synthesis of Aminohydantoins as Potent and Selective Human beta-Secretase (BACE1) Inhibitors with Enhanced Brain Permeability
Bioorg.Med.Chem.Lett., 20, 2010
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6HJR
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