6ZCI

Crystal structure of BRD4-BD1 in complex with NVS-BET-1

Summary for 6ZCI

• Entry DOI: 10.2210/pdb6zci/pdb
• Descriptor: Bromodomain-containing protein 4, (4~{R})-4-(4-chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6-oxidanylidene-pyridin-3-yl)-3-methyl-4~{H}-pyrrolo[3,4-c]pyrazol-6-one (3 entities in total)
• Functional Keywords: chromatin binding, bromodomain, acetylated histone binding, transcription regulation, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 17979.93

Authors

Faller, M. (deposition date: 2020-06-11, release date: 2020-12-23, Last modification date: 2024-01-24)

• Primary citation: Schutzius, G.,Kolter, C.,Bergling, S.,Tortelli, F.,Fuchs, F.,Renner, S.,Guagnano, V.,Cotesta, S.,Rueeger, H.,Faller, M.,Bouchez, L.,Salathe, A.,Nigsch, F.,Richards, S.M.,Louis, M.,Gruber, V.,Aebi, A.,Turner, J.,Grandjean, F.,Li, J.,Dimitri, C.,Thomas, J.R.,Schirle, M.,Blank, J.,Drueckes, P.,Vaupel, A.,Tiedt, R.,Manley, P.W.,Klopp, J.,Hemmig, R.,Zink, F.,Leroy, N.,Carbone, W.,Roma, G.,Keller, C.G.,Dales, N.,Beyerbach, A.,Zimmerlin, A.,Bonenfant, D.,Terranova, R.,Berwick, A.,Sahambi, S.,Reynolds, A.,Jennings, L.L.,Ruffner, H.,Tarsa, P.,Bouwmeester, T.,Driver, V.,Frederiksen, M.,Lohmann, F.,Kirkland, S.; BET bromodomain inhibitors regulate keratinocyte plasticity.; Nat.Chem.Biol., 17:280-290, 2021; PubMed: 33462494; DOI: 10.1038/s41589-020-00716-z

Experimental method

X-RAY DIFFRACTION (1.976 Å)