6VBC
Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041
Summary for 6VBC
Entry DOI | 10.2210/pdb6vbc/pdb |
Descriptor | Probable peptidoglycan D,D-transpeptidase PenA (2 entities in total) |
Functional Keywords | penicillin-binding protein, antibiotic resistance, transpeptidase domain, hydrolase |
Biological source | Neisseria gonorrhoeae |
Total number of polymer chains | 1 |
Total formula weight | 35361.50 |
Authors | Singh, A.,Davies, C. (deposition date: 2019-12-18, release date: 2020-04-15, Last modification date: 2024-03-06) |
Primary citation | Singh, A.,Turner, J.,Tomberg, J.,Fedarovich, A.,Unemo, M.,Nicholas, R.A.,Davies, C. Mutations in Neisseria gonorrhoeae penicillin-binding protein 2 associated with extended-spectrum cephalosporin resistance create an energetic barrier against acylation via restriction of protein dynamics J.Biol.Chem., 2020 |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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