6VBC

Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041

Summary for 6VBC

Entry DOI	10.2210/pdb6vbc/pdb
Descriptor	Probable peptidoglycan D,D-transpeptidase PenA (2 entities in total)
Functional Keywords	penicillin-binding protein, antibiotic resistance, transpeptidase domain, hydrolase
Biological source	Neisseria gonorrhoeae
Total number of polymer chains	1
Total formula weight	35361.50
Authors	Singh, A.,Davies, C. (deposition date: 2019-12-18, release date: 2020-04-15, Last modification date: 2024-03-06)
Primary citation	Singh, A.,Turner, J.,Tomberg, J.,Fedarovich, A.,Unemo, M.,Nicholas, R.A.,Davies, C. Mutations in Neisseria gonorrhoeae penicillin-binding protein 2 associated with extended-spectrum cephalosporin resistance create an energetic barrier against acylation via restriction of protein dynamics J.Biol.Chem., 2020
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation