2JJT

Structure of human CD47 in complex with human signal regulatory protein (SIRP) alpha

Summary for 2JJT

Entry DOI	10.2210/pdb2jjt/pdb
Related	2JJS 2UV3 2VSC
Descriptor	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, LEUKOCYTE SURFACE ANTIGEN CD47, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	signal regulatory protein alpha, immunoglobulin superfamily, transmembrane, phosphoprotein, paired receptor, polymorphism, glycoprotein, cell adhesion, pyrrolidone carboxylic acid, alternative splicing, immunoglobulin domain, sirp, cd47, sirpa, membrane, sh3-binding
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	58202.98
Authors	Hatherley, D.,Graham, S.C.,Turner, J.,Harlos, K.,Stuart, D.I.,Barclay, A.N. (deposition date: 2008-04-22, release date: 2008-08-05, Last modification date: 2023-12-13)
Primary citation	Hatherley, D.,Graham, S.C.,Turner, J.,Harlos, K.,Stuart, D.I.,Barclay, A.N. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol. Cell, 31:266-277, 2008 Cited by PubMed: 18657508 DOI: 10.1016/j.molcel.2008.05.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation