Structure of human CD47 in complex with human signal regulatory protein (SIRP) alpha

Summary for 2JJT

Related2JJS 2VSC 2UV3
DescriptorTYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, LEUKOCYTE SURFACE ANTIGEN CD47, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywordssignal regulatory protein alpha, immunoglobulin superfamily, transmembrane, phosphoprotein, paired receptor, polymorphism, glycoprotein, cell adhesion, pyrrolidone carboxylic acid, alternative splicing, immunoglobulin domain, sirp, cd47, sirpa, membrane, sh3-binding
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains4
Total molecular weight58202.98
Hatherley, D.,Graham, S.C.,Turner, J.,Harlos, K.,Stuart, D.I.,Barclay, A.N. (deposition date: 2008-04-22, release date: 2008-08-05, Last modification date: 2020-07-29)
Primary citation
Hatherley, D.,Graham, S.C.,Turner, J.,Harlos, K.,Stuart, D.I.,Barclay, A.N.
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Mol. Cell, 31:266-277, 2008
PubMed: 18657508 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2008.05.026
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2883 0.2% 0.8% 4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-12