2JJT

Structure of human CD47 in complex with human signal regulatory protein (SIRP) alpha

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1	polymer	126	13919.6	2	UniProt (P78324) Pfam (PF07686) In PDB	HOMO SAPIENS (HUMAN)	SIRP ALPHA, SHP SUBSTRATE 1, SHPS-1, INHIBITORY RECEPTOR SHPS-1, SIGNAL REGULATORY PROTEIN ALPHA-1, SIRP-ALPHA-1, SIRP-ALPHA-2, SIRP-ALPHA- 3, MYD-1 ANTIGEN, BRAIN IG-LIKE MOLECULE WITH TYROSINE- BASED ACTIVATION MOTIFS, BIT, MACROPHAGE FUSION RECEPTOR, P84, CD172A ANTIGEN
2	C, D	LEUKOCYTE SURFACE ANTIGEN CD47	polymer	127	14518.3	2	UniProt (Q08722) Pfam (PF08204) In PDB	HOMO SAPIENS (HUMAN)	CD47, INTEGRIN-ASSOCIATED PROTEIN, IAP, ANTIGENIC SURFACE DETERMINANT PROTEIN OA3, PROTEIN MER6
3	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
4		water	water		18.0	43	Chemie (HOH)

Sequence modifications

A, B: 1 - 118 (UniProt: P78324)
A, B: 119 - 126 (PDB: 2JJT)
C, D: 1 - 118 (UniProt: Q08722)

PDB	External Database	Details
Gly 15	Cys 33	engineered mutation

C, D: 119 - 127 (PDB: 2JJT)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	56875.7
Non-Polymers*	Number of molecules	6
	Total formula weight	1327.2
All*	Total formula weight	58203.0

*Water molecules are not included.