2UV3

Structure of the signal-regulatory protein (SIRP) alpha domain that binds CD47.

Summary for 2UV3

DescriptorTYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ... (4 entities in total)
Functional Keywordscd47-binding domain of sirp-alpha, receptor, membrane, sh3- binding, glycoprotein, transmembrane, phosphorylation, human sirp-alpha n terminal v domain, immunoglobulin domain, signal-regulatory protein alpha
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight28805.98
Authors
Hatherley, D.,Harlos, K.,Dunlop, D.C.,Stuart, D.I.,Barclay, A.N. (deposition date: 2007-03-08, release date: 2007-03-27, Last modification date: 2011-07-13)
Primary citation
Hatherley, D.,Harlos, K.,Dunlop, D.C.,Stuart, D.I.,Barclay, A.N.
The Structure of the Macrophage Signal Regulatory Protein Alpha (Sirpalpha) Inhibitory Receptor Reveals a Binding Face Reminiscent of that Used by T Cell Receptors.
J.Biol.Chem., 282:14567-, 2007
PubMed: 17369261 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M611511200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.257502.0%7.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution