2UV3
Structure of the signal-regulatory protein (SIRP) alpha domain that binds CD47.
Summary for 2UV3
Entry DOI | 10.2210/pdb2uv3/pdb |
Descriptor | TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ... (4 entities in total) |
Functional Keywords | cd47-binding domain of sirp-alpha, receptor, membrane, sh3- binding, glycoprotein, transmembrane, phosphorylation, human sirp-alpha n terminal v domain, immunoglobulin domain, signal-regulatory protein alpha |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 28805.98 |
Authors | Hatherley, D.,Harlos, K.,Dunlop, D.C.,Stuart, D.I.,Barclay, A.N. (deposition date: 2007-03-08, release date: 2007-03-27, Last modification date: 2024-05-01) |
Primary citation | Hatherley, D.,Harlos, K.,Dunlop, D.C.,Stuart, D.I.,Barclay, A.N. The Structure of the Macrophage Signal Regulatory Protein Alpha (Sirpalpha) Inhibitory Receptor Reveals a Binding Face Reminiscent of that Used by T Cell Receptors. J.Biol.Chem., 282:14567-, 2007 Cited by PubMed: 17369261DOI: 10.1074/JBC.M611511200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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