2UV3
Structure of the signal-regulatory protein (SIRP) alpha domain that binds CD47.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1 | polymer | 126 | 13919.6 | 2 | UniProt (P78324) Pfam (PF07686) | HOMO SAPIENS (HUMAN) | SIGNAL-REGULATORY PROTEIN ALPHA N-TERMINAL DOMAIN, SHP SUBSTRATE 1, SHPS-1, INHIBITORY RECEPTOR SHPS-1, SIGNAL-REGULATORY PROTEIN ALPHA-1, SIRP-ALPHA-1, SIRP-ALPHA-2, SIRP-ALPHA-3, MYD-1 ANTIGEN, BRAIN IG-LIKE MOLECULE WITH TYROSINE-BASED ACTIVATION MOTIFS, BIT, MACROPHAGE FUSION RECEPTOR, P84, CD172A ANTIGEN |
| 2 | C, I (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 3 | D, E, F, G, H... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | K, L (A, B) | water | water | 18.0 | 298 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27839.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 966.9 | |
| All* | Total formula weight | 28806.0 |
