2UV3

Structure of the signal-regulatory protein (SIRP) alpha domain that binds CD47.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1	polymer	126	13919.6	2	UniProt (P78324) Pfam (PF07686) In PDB	HOMO SAPIENS (HUMAN)	SIGNAL-REGULATORY PROTEIN ALPHA N-TERMINAL DOMAIN, SHP SUBSTRATE 1, SHPS-1, INHIBITORY RECEPTOR SHPS-1, SIGNAL-REGULATORY PROTEIN ALPHA-1, SIRP-ALPHA-1, SIRP-ALPHA-2, SIRP-ALPHA-3, MYD-1 ANTIGEN, BRAIN IG-LIKE MOLECULE WITH TYROSINE-BASED ACTIVATION MOTIFS, BIT, MACROPHAGE FUSION RECEPTOR, P84, CD172A ANTIGEN
2	A, B	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
3	A, B	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
4		water	water		18.0	298	Chemie (HOH)

Sequence modifications

A, B: 1 - 118 (UniProt: P78324)
A, B: 119 - 126 (PDB: 2UV3)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	27839.1
Non-Polymers*	Number of molecules	8
	Total formula weight	966.9
All*	Total formula weight	28806.0

*Water molecules are not included.