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2UV3

Structure of the signal-regulatory protein (SIRP) alpha domain that binds CD47.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BTYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1polymer12613919.62UniProt (P78324)
Pfam (PF07686)
In PDB
HOMO SAPIENS (HUMAN)SIGNAL-REGULATORY PROTEIN ALPHA N-TERMINAL DOMAIN, SHP SUBSTRATE 1, SHPS-1, INHIBITORY RECEPTOR SHPS-1, SIGNAL-REGULATORY PROTEIN ALPHA-1, SIRP-ALPHA-1, SIRP-ALPHA-2, SIRP-ALPHA-3, MYD-1 ANTIGEN, BRAIN IG-LIKE MOLECULE WITH TYROSINE-BASED ACTIVATION MOTIFS, BIT, MACROPHAGE FUSION RECEPTOR, P84, CD172A ANTIGEN
2A, B2-(N-MORPHOLINO)-ETHANESULFONIC ACIDnon-polymer195.22Chemie (MES)
3A, BSULFATE IONnon-polymer96.16Chemie (SO4)
4waterwater18.0298Chemie (HOH)
Sequence modifications
A, B: 1 - 118 (UniProt: P78324)
A, B: 119 - 126 (PDB: 2UV3)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight27839.1
Non-Polymers*Number of molecules8
Total formula weight966.9
All*Total formula weight28806.0
*Water molecules are not included.

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PDB entries from 2024-09-18

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