6VBL

Crystal structure of the transpeptidase domain of PBP2 from the Neisseria gonorrhoeae cephalosporin decreased susceptibility strain 35/02

Summary for 6VBL

Entry DOI	10.2210/pdb6vbl/pdb
Descriptor	Probable peptidoglycan D,D-transpeptidase PenA (2 entities in total)
Functional Keywords	penicillin-binding protein, transpeptidase domain, antibiotic resistance, hydrolase
Biological source	Neisseria gonorrhoeae
Total number of polymer chains	1
Total formula weight	35331.38
Authors	Singh, A.,Davies, C. (deposition date: 2019-12-19, release date: 2020-04-15, Last modification date: 2023-10-11)
Primary citation	Singh, A.,Turner, J.,Tomberg, J.,Fedarovich, A.,Unemo, M.,Nicholas, R.A.,Davies, C. Mutations in Neisseria gonorrhoeae penicillin-binding protein 2 associated with extended-spectrum cephalosporin resistance create an energetic barrier against acylation via restriction of protein dynamics J.Biol.Chem., 2020
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation