1MBZ
 
 | | BETA-LACTAM SYNTHETASE WITH TRAPPED INTERMEDIATE | | 分子名称: | ARGININE-N-METHYLCARBONYL PHOSPHORIC ACID 5'-ADENOSINE ESTER, BETA-LACTAM SYNTHETASE, GLYCEROL, ... | | 著者 | Miller, M.T, Bachmann, B.O, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2002-08-04 | | 公開日 | 2002-10-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
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5KBZ
 | | Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic | | 分子名称: | (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate, Noranthrone synthase | | 著者 | Tsai, S.C, Burkart, M.D, Townsend, C.A, Barajas, J.F, Shakya, G, Topper, C.L, Moreno, G, Jackson, D.R, Rivera, H, La Clair, J.J, Vagstad, A. | | 登録日 | 2016-06-03 | | 公開日 | 2017-05-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5MPT
 | | Structure of the citrinin polyketide synthase CMeT domain | | 分子名称: | 1,2-ETHANEDIOL, Citrinin polyketide synthase, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Herbst, D.A, Storm, P.A, Townsend, C.A, Maier, T. | | 登録日 | 2016-12-19 | | 公開日 | 2017-02-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | | 主引用文献 | Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin.
Cell Chem Biol, 24, 2017
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6FIJ
 | | Structure of the loading/condensing region (SAT-KS-MAT) of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, ... | | 著者 | Herbst, D.A, Jakob, R.P, Townsend, C.A, Maier, T. | | 登録日 | 2018-01-18 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
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6FIK
 | | ACP2 crosslinked to the KS of the loading/condensing region of the CTB1 PKS | | 分子名称: | Polyketide synthase | | 著者 | Herbst, D.A, Huitt-Roehl, C.R, Jakob, R.P, Townsend, C.A, Maier, T. | | 登録日 | 2018-01-18 | | 公開日 | 2018-03-21 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | | 主引用文献 | The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
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1Q19
 | | Carbapenam Synthetase | | 分子名称: | (2S,5S)-5-CARBOXYMETHYLPROLINE, CarA, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | | 著者 | Miller, M.T, Gerratana, B, Stapon, A, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2003-07-18 | | 公開日 | 2003-11-04 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structure of Carbapenam Synthetase (CarA)
J.Biol.Chem., 278, 2003
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1Q15
 | | Carbapenam Synthetase | | 分子名称: | CarA | | 著者 | Miller, M.T, Gerratana, B, Stapon, A, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2003-07-18 | | 公開日 | 2003-11-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of Carbapenam Synthetase (CarA)
J.Biol.Chem., 278, 2003
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1JGT
 | | CRYSTAL STRUCTURE OF BETA-LACTAM SYNTHETASE | | 分子名称: | BETA-LACTAM SYNTHETASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, GLYCEROL, ... | | 著者 | Miller, M.T, Bachmann, B.O, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2001-06-26 | | 公開日 | 2001-12-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine.
Nat.Struct.Biol., 8, 2001
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1MC1
 | | BETA-LACTAM SYNTHETASE WITH PRODUCT (DGPC), AMP AND PPI | | 分子名称: | ADENOSINE MONOPHOSPHATE, BETA-LACTAM SYNTHETASE, DEOXYGUANIDINOPROCLAVAMINIC ACID, ... | | 著者 | Miller, M.T, Bachmann, B.O, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2002-08-04 | | 公開日 | 2002-10-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
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1M1Z
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1MB9
 | | BETA-LACTAM SYNTHETASE COMPLEXED WITH ATP | | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, BETA-LACTAM SYNTHETASE, ... | | 著者 | Miller, M.T, Bachmann, B.O, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2002-08-02 | | 公開日 | 2002-10-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
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4IHE
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4IHD
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5K69
 | | Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T224 | | 分子名称: | (2~{S},3~{R},4~{R})-4-(1~{H}-indol-3-ylsulfanyl)-3-methyl-2-[(2~{S},3~{S})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, GLYCEROL, L,D-transpeptidase 2 | | 著者 | Lamichhane, G, Ginell, S.L, Kumar, P. | | 登録日 | 2016-05-24 | | 公開日 | 2016-11-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials.
Nat. Chem. Biol., 13, 2017
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5DC2
 | | X-RAY CRYSTAL STRUCTURE OF A ENZYMATICALLY DEGRADED BIAPENEM-ADDUCT OF L,D-TRANSPEPTIDASE 2 FROM MYCOBACTERIUM TUBERCULOSIS | | 分子名称: | (4S)-4-methyl-2,5,7-trioxoheptanoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pan, Y, Basta, L, Lamichhane, G, Bianchet, M.A. | | 登録日 | 2015-08-23 | | 公開日 | 2016-10-05 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.182 Å) | | 主引用文献 | Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.
BMC Biochem., 18, 2017
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5D7H
 | | X-RAY CRYSTAL STRUCTURE OF L,D TRANSPEPTIDASE 2 FROM MYCOBACTERIUM TUBERCULOSIS | | 分子名称: | GLYCEROL, L,D-transpeptidase 2, SULFATE ION | | 著者 | Saavedra, H, Basta, L.A, Lamichhane, G, Bianchet, M.A. | | 登録日 | 2015-08-13 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem.
BMC Biochem., 18, 2017
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5DUJ
 | | Crystal structure of ldtMt2 in complex with Faropenem adduct | | 分子名称: | (2R,5R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydro-1,3-thiazole-4-carboxylic acid, BETA-MERCAPTOETHANOL, L,D-transpeptidase 2, ... | | 著者 | Kumar, P, Lamichhane, G. | | 登録日 | 2015-09-18 | | 公開日 | 2016-09-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials.
Nat. Chem. Biol., 13, 2017
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5DU7
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4Z7A
 | | Structural and biochemical characterization of a non-functionally redundant M. tuberculosis (3,3) L,D-Transpeptidase, LdtMt5. | | 分子名称: | ACETYL GROUP, DI(HYDROXYETHYL)ETHER, Mycobacterium tuberculosis (3,3)L,D-Transpeptidase type 5, ... | | 著者 | Basta, L, Ghosh, A, Pan, Y, Jakoncic, J, Lloyd, E, Townsend, G, Lamichhane, G, Bianchet, M.A. | | 登録日 | 2015-04-06 | | 公開日 | 2015-09-02 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis.
J.Biol.Chem., 290, 2015
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6BOI
 | | Crystal Structure of LdtMt2 (56-408) with a panipenem adduct at the active site cysteine-354 | | 分子名称: | (3S,5R)-5-[(2R,3R)-1,3-dihydroxybutan-2-yl]-3-({(3R)-1-[(1E)-ethanimidoyl]pyrrolidin-3-yl}sulfanyl)-L-proline, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Saavedra, H, Bianchet, M.A. | | 登録日 | 2017-11-20 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | | 主引用文献 | Structures and Mechanism of Inhibition of Mycobacterium tuberculosis L,D-transpeptidase 2 by Panipenem
To Be Published
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5E1I
 | | Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T210 | | 分子名称: | (2S,3R,4R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-(methylsulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, GLYCEROL, L,D-transpeptidase 2, ... | | 著者 | Kumar, P, Ginell, S.L, Lamichhane, G. | | 登録日 | 2015-09-29 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials.
Nat. Chem. Biol., 13, 2017
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5E51
 | | Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 1 with Faropenem adduct | | 分子名称: | (3R)-3-hydroxybutanal, L,D-transpeptidase 1 | | 著者 | Kumar, P, Lamichhane, G, Ginell, S.L. | | 登録日 | 2015-10-07 | | 公開日 | 2016-10-26 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials.
Nat. Chem. Biol., 13, 2017
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3HRR
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5DVP
 | | Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with Doripenem adduct | | 分子名称: | (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, L,D-transpeptidase 2, PHOSPHONOACETALDEHYDE, ... | | 著者 | Kumar, P, Lamichhane, G. | | 登録日 | 2015-09-21 | | 公開日 | 2016-09-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials.
Nat. Chem. Biol., 13, 2017
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5E1G
 | | Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T208 | | 分子名称: | (2~{S},3~{R},4~{R})-4-(2-cyclohexyloxy-2-oxidanylidene-ethyl)sulfanyl-3-methyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, L,D-transpeptidase 2 | | 著者 | Kumar, P, Lamichhane, G, Ginell, S.L. | | 登録日 | 2015-09-29 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.852 Å) | | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials.
Nat. Chem. Biol., 13, 2017
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