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5KBZ

Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic

Summary for 5KBZ
Entry DOI10.2210/pdb5kbz/pdb
Related3hrr
DescriptorNoranthrone synthase, (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate (3 entities in total)
Functional Keywordsaflatoxin, polyketide synthase, polyketide, product template, dehydratase, double hot dog fold, cyclase, transcription
Biological sourceAspergillus parasiticus
Total number of polymer chains2
Total formula weight84367.51
Authors
Tsai, S.C.,Burkart, M.D.,Townsend, C.A.,Barajas, J.F.,Shakya, G.,Topper, C.L.,Moreno, G.,Jackson, D.R.,Rivera, H.,La Clair, J.J.,Vagstad, A. (deposition date: 2016-06-03, release date: 2017-05-10, Last modification date: 2023-09-27)
Primary citationBarajas, J.F.,Shakya, G.,Moreno, G.,Rivera, H.,Jackson, D.R.,Topper, C.L.,Vagstad, A.L.,La Clair, J.J.,Townsend, C.A.,Burkart, M.D.,Tsai, S.C.
Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc. Natl. Acad. Sci. U.S.A., 114:E4142-E4148, 2017
Cited by
PubMed: 28484029
DOI: 10.1073/pnas.1609001114
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.803 Å)
Structure validation

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