5W1Y
| SETD8 in complex with a covalent inhibitor | 分子名称: | 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione, N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Yu, W, Li, Y, Blum, G, Luo, M, Pittella-Silva, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2017-06-05 | 公開日 | 2017-06-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | SETD8 in complex with a covalent inhibitor to be published
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1HQL
| The xenograft antigen in complex with the B4 isolectin of Griffonia simplicifolia lectin-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, LECTIN, ... | 著者 | Tempel, W, Lipscomb, L.A, Rose, J.P, Woods, R.J. | 登録日 | 2000-12-18 | 公開日 | 2002-01-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The xenograft antigen bound to Griffonia simplicifolia lectin 1-B(4). X-ray crystal structure of the complex and molecular dynamics characterization of the binding site. J.Biol.Chem., 277, 2002
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5KCH
| SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy into weak electron density | 分子名称: | 4-methoxy-N-[(pyridin-2-yl)methyl]aniline, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase SETDB1, ... | 著者 | Tempel, W, Harding, R.J, Mader, P, Dobrovetsky, E, Walker, J.R, Brown, P.J, Schapira, M, Collins, P, Pearce, N, Brandao-Neto, J, Douangamath, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Santhakumar, V, Structural Genomics Consortium (SGC) | 登録日 | 2016-06-06 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy To Be Published
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5KCO
| SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy | 分子名称: | DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase SETDB1, SULFATE ION, ... | 著者 | Tempel, W, Harding, R.J, Mader, P, Dobrovetsky, E, Walker, J.R, Brown, P.J, Schapira, M, Collins, P, Pearce, N, Brandao-Neto, J, Douangamath, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Santhakumar, V, Structural Genomics Consortium (SGC) | 登録日 | 2016-06-06 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy To Be Published
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1NXC
| Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases) | 分子名称: | CALCIUM ION, Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Tempel, W, Liu, Z.-J, Karaveg, K, Rose, J, Moremen, K.W, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2003-02-10 | 公開日 | 2004-05-04 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases J.Biol.Chem., 279, 2004
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6EDF
| Fragment of a tyrosine-protein kinase | 分子名称: | FYN, GLYCEROL, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Huang, H, Sochirca, I, Liu, K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Sidhu, S.S, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2018-08-09 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Fragment of a tyrosine-protein kinase To be Published
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1UPS
| GlcNAc[alpha]1-4Gal releasing endo-[beta]-galactosidase from Clostridium perfringens | 分子名称: | CALCIUM ION, GLCNAC-ALPHA-1,4-GAL-RELEASING ENDO-BETA-GALACTOSIDASE | 著者 | Tempel, W, Liu, Z.-J, Horanyi, P.S, Deng, L, Lee, D, Newton, M.G, Rose, J.P, Ashida, H, Li, S.-C, Li, Y.-T, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2003-10-10 | 公開日 | 2004-11-25 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Three-dimensional structure of GlcNAcalpha1-4Gal releasing endo-beta-galactosidase from Clostridium perfringens. Proteins, 59, 2005
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6MEW
| RFXANK ankyrin repeats in complex with a RFX7 peptide | 分子名称: | DNA-binding protein RFXANK, RFX7 peptide, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Xu, C, Dong, A, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2018-09-07 | 公開日 | 2018-10-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | RFXANK ankyrin repeats in complex with a RFX7 peptide to be published
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6N8U
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5C8H
| Crystal structure of ORC2 C-terminal domain | 分子名称: | Origin recognition complex subunit 2, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Xu, C, Dong, A, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2015-06-25 | 公開日 | 2015-07-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Crystal structure of ORC2 C-terminal domain To Be Published
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5UPD
| Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1) | 分子名称: | Histone-lysine N-methyltransferase NSD3, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ... | 著者 | Tempel, W, Yu, W, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2017-02-02 | 公開日 | 2017-02-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1) To Be Published
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1YBX
| Conserved hypothetical protein Cth-383 from Clostridium thermocellum | 分子名称: | Conserved hypothetical protein, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Chang, J, Zhao, M, Habel, J, Kataeva, I, Xu, H, Chen, L, Lee, D, Nguyen, J, Chang, S.-H, Horanyi, P, Florence, Q, Zhou, W, Lin, D, Zhang, H, Ljundahl, L, Liu, Z.-J, Rose, J, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2004-12-21 | 公開日 | 2005-02-01 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Conserved hypothetical protein Cth-383 from Clostridium thermocellum To be published
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3KUP
| Crystal Structure of the CBX3 Chromo Shadow Domain | 分子名称: | Chromobox protein homolog 3, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Li, Z, Li, Y, Kozieradzki, I, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | 登録日 | 2009-11-27 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Crystal Structure of the CBX3 Chromo Shadow Domain to be published
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2PXX
| Human putative methyltransferase MGC2408 | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION, Uncharacterized protein MGC2408 | 著者 | Tempel, W, Wu, H, Dombrovsky, L, Zeng, H, Zhu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2007-05-14 | 公開日 | 2007-05-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene. Proteins, 74, 2009
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4QPN
| Crystal Structure of Human Methyltransferase-Like Protein 21B | 分子名称: | Protein-lysine methyltransferase METTL21B, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | 著者 | Tempel, W, Hong, B.S, Seitova, A, He, H, Li, Y, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2014-06-24 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Crystal Structure of Human Methyltransferase-Like Protein 21B TO BE PUBLISHED
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4PWY
| Crystal structure of a Calmodulin-lysine N-methyltransferase fragment | 分子名称: | Calmodulin-lysine N-methyltransferase, GLYCEROL, MALONATE ION, ... | 著者 | Tempel, W, Hong, B.S, Walker, J.R, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2014-03-21 | 公開日 | 2014-04-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of a Calmodulin-lysine N-methyltransferase fragment TO BE PUBLISHED
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4L1M
| Structure of the first RCC1-like domain of HERC2 | 分子名称: | E3 ubiquitin-protein ligase HERC2, SULFATE ION, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Khan, M.B, Dong, A, Hu, J, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | 登録日 | 2013-06-03 | 公開日 | 2013-07-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of the first RCC1-like domain of HERC2 TO BE PUBLISHED
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1XK8
| Divalent cation tolerant protein CUTA from Homo sapiens O60888 | 分子名称: | Divalent cation tolerant protein CUTA, SODIUM ION | 著者 | Tempel, W, Chen, L, Liu, Z.-J, Lee, D, Shah, A, Dailey, T.A, Mayer, M.R, Arendall III, W.B, Rose, J.P, Dailey, H.A, Richardson, J.S, Richardson, D.C, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2004-09-27 | 公開日 | 2004-10-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Divalent cation tolerant protein CUTA from Homo sapiens O60888 To be published
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3RPX
| Crystal structure of complement component 1, q subcomponent binding protein, C1QBP | 分子名称: | Complement component 1 Q subcomponent-binding protein, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Tong, Y, Crombet, L, Shen, Y, Guan, X, Nedyalkova, L, Walker, J.R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-04-27 | 公開日 | 2011-05-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Crystal structure of complement component 1, q subcomponent binding protein, C1QBP to be published
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4OCT
| Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate | 分子名称: | 2-OXOGLUTARIC ACID, MANGANESE (II) ION, RNA demethylase ALKBH5, ... | 著者 | Tempel, W, Chao, X, Liu, K, Dong, A, Cerovina, T, He, H, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2014-01-09 | 公開日 | 2014-04-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J.Biol.Chem., 289, 2014
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3UXG
| Crystal structure of RFXANK | 分子名称: | DNA-binding protein RFXANK, Histone deacetylase 4, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Chao, X, Bian, C, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2011-12-05 | 公開日 | 2012-06-13 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock. Sci.Signal., 5, 2012
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3L42
| PWWP domain of human bromodomain and PHD finger containing protein 1 | 分子名称: | Peregrin, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Zeng, H, Ni, S, Amaya, M.F, Dong, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2009-12-18 | 公開日 | 2010-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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1NNQ
| rubrerythrin from Pyrococcus furiosus Pfu-1210814 | 分子名称: | Rubrerythrin, ZINC ION | 著者 | Liu, Z.-J, Tempel, W, Schubot, F.D, Shah, A, Arendall III, W.B, Rose, J.P, Richardson, D.C, Richardson, J.S, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2003-01-14 | 公開日 | 2004-03-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin Proteins, 57, 2004
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5I3L
| DPF3b in complex with H3K14ac peptide | 分子名称: | 1,2-ETHANEDIOL, H3K14ac peptide, SODIUM ION, ... | 著者 | Tempel, W, Liu, Y, Walker, J.R, Zhao, A, Qin, S, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2016-02-10 | 公開日 | 2016-02-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of DPF3b in complex with an acetylated histone peptide. J.Struct.Biol., 195, 2016
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6P9G
| Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid | 分子名称: | (2R)-2-(4-oxoquinazolin-3(4H)-yl)propanoic acid, UNKNOWN ATOM OR ION, Ubiquitin carboxyl-terminal hydrolase 5, ... | 著者 | Tempel, W, Mann, M.K, Harding, R.J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Schapira, M, Structural Genomics Consortium (SGC) | 登録日 | 2019-06-10 | 公開日 | 2019-09-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. J.Med.Chem., 62, 2019
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