4V1J
 
 | | Structure of Neisseria meningitidis Major Pillin | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, FIMBRIAL PROTEIN | | 著者 | Harding, R.J, Exley, R, Tang, C.M, Caesar, J.J.E, Lea, S.M. | | 登録日 | 2014-09-29 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Tstructure of Neisseria Meningitidis Major Pillin
To be Published
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2W80
 | | Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H | | 分子名称: | COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN | | 著者 | Schneider, M.C, Prosser, B.E, Caesar, J.J.E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J.E, Deane, J.E, Sim, R.B, Roversi, P, Johnson, S, Tang, C.M, Lea, S.M. | | 登録日 | 2009-01-08 | | 公開日 | 2009-03-03 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.
Nature, 458, 2009
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6FK5
 | | Structure of 3' phosphatase NExo (D146N) from Neisseria bound to DNA substrate in presence of magnesium ion | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*CP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*AP*GP*A)-3'), MAGNESIUM ION, ... | | 著者 | Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S. | | 登録日 | 2018-01-23 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis.
Nucleic Acids Res., 46, 2018
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6FKE
 | | Structure of 3' phosphatase NExo (D146N) from Neisseria bound to product DNA hairpin | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*GP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*A)-3'), Exodeoxyribonuclease III, ... | | 著者 | Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S. | | 登録日 | 2018-01-23 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | | 主引用文献 | Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis.
Nucleic Acids Res., 46, 2018
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6FK4
 | | Structure of 3' phosphatase NExo (WT) from Neisseria bound to DNA substrate | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*GP*CP*TP*AP*GP*CP*GP*AP*AP*GP*CP*TP*AP*GP*A)-3'), Exodeoxyribonuclease III | | 著者 | Silhan, J, Zhao, Q, Boura, E, Thomson, H, Foster, A, Tang, C.M, Freemont, P.S, Baldwin, G.S. | | 登録日 | 2018-01-23 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.297 Å) | | 主引用文献 | Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis.
Nucleic Acids Res., 46, 2018
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4A5P
 | | Structure of the Shigella flexneri MxiA protein | | 分子名称: | 1,2-ETHANEDIOL, PROTEIN MXIA | | 著者 | Abrusci, P, Vegara-Irigaray, M, Johnson, S, Roversi, P, Friede, M.E, Deane, J.E, Tang, C.M, Lea, S.M. | | 登録日 | 2011-10-26 | | 公開日 | 2012-11-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Architecture of the major component of the type III secretion system export apparatus.
Nat.Struct.Mol.Biol., 20, 2013
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2W81
 | | Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H | | 分子名称: | COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN | | 著者 | Schneider, M.C, Prosser, B.E, Caesar, J.J.E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J.E, Deane, J.E, Sim, R.B, Roversi, P, Johnson, S, Tang, C.M, Lea, S.M. | | 登録日 | 2009-01-08 | | 公開日 | 2009-03-03 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates.
Nature, 458, 2009
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2YBY
 | | Structure of domains 6 and 7 of the mouse complement regulator Factor H | | 分子名称: | 1,2-ETHANEDIOL, COMPLEMENT FACTOR H | | 著者 | Everett, R.J, Caesar, J.J.E, Johnson, S.J, Tang, C.M, Lea, S.M. | | 登録日 | 2011-03-30 | | 公開日 | 2012-04-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
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5NQY
 | | Structure of a fHbp(V1.4):PorA(P1.16) chimera. Fusion at fHbp position 309. | | 分子名称: | Factor H binding protein variant B16_001,Major outer membrane protein P.IA,Factor H binding protein variant B16_001 | | 著者 | Johnson, S, Hollingshead, S, Lea, S.M, Tang, C.M. | | 登録日 | 2017-04-21 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
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5NQZ
 | | Structure of a fHbp(V1.1):PorA(P1.16) chimera. Fusion at fHbp position 309. | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Factor H binding protein,Major outer membrane protein P.IA,Factor H binding protein, ... | | 著者 | Johnson, S, Hollingshead, S, Lea, S.M, Tang, C.M. | | 登録日 | 2017-04-21 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
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5NQX
 | | Structure of a fHbp(V1.1):PorA(P1.16) chimera. Fusion at fHbp position 294. | | 分子名称: | Factor H binding protein,Major outer membrane protein P.IA,Factor H binding protein | | 著者 | Johnson, S, Jongerius, I, Lea, S.M, Tang, C.M. | | 登録日 | 2017-04-21 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.66 Å) | | 主引用文献 | Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
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5NQP
 | | Structure of a fHbp(V1.4):PorA(P1.16) chimera. Fusion at fHbp position 151. | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Factor H binding protein variant B16_001,Major outer membrane protein P.IA,Factor H binding protein variant B16_001, ... | | 著者 | Johnson, S, Hollingshead, S, Lea, S.M, Tang, C.M. | | 登録日 | 2017-04-20 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Structure-based design of chimeric antigens for multivalent protein vaccines.
Nat Commun, 9, 2018
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4B5H
 | | Substate bound inactive mutant of Neisseria AP endonuclease in presence of metal ions | | 分子名称: | 5'-D(*CP*GP*AP*TP*GP*GP*GP*TP*AP*GP*CP)-3', 5'-D(*GP*CP*TP*AP*CP*3DRP*CP*AP*TP*CP*GP)-3', MANGANESE (II) ION, ... | | 著者 | Lu, D, Silhan, J, MacDonald, J.T, Carpenter, E.P, Jensen, K, Tang, C.M, Baldwin, G.S, Freemont, P.S. | | 登録日 | 2012-08-03 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
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4B5M
 | | Neisseria AP endonuclease bound to the substrate with a cytosine orphan base | | 分子名称: | 5'-D(*3DRP*CP*AP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*TP*GP*CP*GP*TP*AP*GP*CP)-3', 5'-D(*GP*CP*TP*AP*CP)-3', ... | | 著者 | Lu, D, Silhan, J, MacDonald, J.T, Carpenter, E.P, Jensen, K, Tang, C.M, Baldwin, G.S, Freemont, P.S. | | 登録日 | 2012-08-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.758 Å) | | 主引用文献 | Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
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4AYI
 | | Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 Wild type | | 分子名称: | 1,2-ETHANEDIOL, COMPLEMENT FACTOR H, LIPOPROTEIN GNA1870 CCOMPND 7 | | 著者 | Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M. | | 登録日 | 2012-06-21 | | 公開日 | 2012-11-07 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
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4B5I
 | | Product complex of Neisseria AP endonuclease in presence of metal ions | | 分子名称: | 5'-D(*3DRP*CP*AP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*TP*GP*GP*GP*TP*AP*GP*CP)-3', 5'-D(*GP*CP*TP*AP*CP)-3', ... | | 著者 | Lu, D, Silhan, J, MacDonald, J.T, Carpenter, E.P, Jensen, K, Tang, C.M, Baldwin, G.S, Freemont, P.S. | | 登録日 | 2012-08-03 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.555 Å) | | 主引用文献 | Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
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4AYM
 | | Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 P106A mutant | | 分子名称: | COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN | | 著者 | Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M. | | 登録日 | 2012-06-21 | | 公開日 | 2012-11-07 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
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4AYD
 | | Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 R106A mutant | | 分子名称: | 1,2-ETHANEDIOL, COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN | | 著者 | Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M. | | 登録日 | 2012-06-20 | | 公開日 | 2012-11-07 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules
Plos Pathog., 8, 2012
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4AYN
 | | Structure of the C-terminal barrel of Neisseria meningitidis FHbp Variant 2 | | 分子名称: | FACTOR H-BINDING PROTEIN, SULFATE ION | | 著者 | Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M. | | 登録日 | 2012-06-21 | | 公開日 | 2012-11-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
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4AYE
 | | Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 E283AE304A mutant | | 分子名称: | 1,2-ETHANEDIOL, COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN | | 著者 | Johnson, S, Tan, L, van der Veen, S, Caesar, J, Goicoechea De Jorge, E, Everett, R.J, Bai, X, Exley, R.M, Ward, P.N, Ruivo, N, Trivedi, K, Cumber, E, Jones, R, Newham, L, Staunton, D, Borrow, R, Pickering, M, Lea, S.M, Tang, C.M. | | 登録日 | 2012-06-20 | | 公開日 | 2012-11-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
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4B5J
 | | Neisseria AP endonuclease bound to the substrate with an orphan Adenine base | | 分子名称: | 5'-D(*CP*GP*AP*TP*GP*AP*GP*TP*AP*GP*CP)-3', 5'-D(*GP*CP*TP*AP*CP*(3DR)P*CP*AP*TP*CP*GP)-3', PUTATIVE EXODEOXYRIBONUCLEASE | | 著者 | Lu, D, Silhan, J, MacDonald, J.T, Carpenter, E.P, Jensen, K, Tang, C.M, Baldwin, G.S, Freemont, P.S. | | 登録日 | 2012-08-03 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
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4B5G
 | | Substrate bound Neisseria AP endonuclease in absence of metal ions (crystal form 2) | | 分子名称: | 5'-D(*CP*GP*AP*TP*GP*GP*GP*TP*AP*GP*CP)-3', 5'-D(*GP*CP*TP*AP*CP*(3DR)P*CP*AP*TP*CP*GP)-3', EXODEOXYRIBONUCLEASE | | 著者 | Lu, D, Silhan, J, MacDonald, J.T, Carpenter, E.P, Jensen, K, Tang, C.M, Baldwin, G.S, Freemont, P.S. | | 登録日 | 2012-08-03 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
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4B5F
 | | Substrate bound Neisseria AP endonuclease in absence of metal ions (crystal form 1) | | 分子名称: | 5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*CP)-3', 5'-D(*GP*CP*TP*AP*CP*3DRP*GP*AP*TP*CP*GP)-3', PUTATIVE EXODEOXYRIBONUCLEASE | | 著者 | Lu, D, Silhan, J, MacDonald, J.T, Carpenter, E.P, Jensen, K, Tang, C.M, Baldwin, G.S, Freemont, P.S. | | 登録日 | 2012-08-03 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.005 Å) | | 主引用文献 | Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
Proc. Natl. Acad. Sci. U.S.A., 109, 2012
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6SD6
 | | Structure of VapBC from Shigella sonnei | | 分子名称: | Antitoxin, tRNA(fMet)-specific endonuclease VapC | | 著者 | Lea, S.M, Hollingshead, S. | | 登録日 | 2019-07-26 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Polymorphisms in the VapBC toxin:antitoxin system mediate high frequency plasmid loss in Shigella sonnei
To Be Published
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3DKC
 | | Structure of MET receptor tyrosine kinase in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Hepatocyte growth factor receptor, ... | | 著者 | Hendle, J. | | 登録日 | 2008-06-24 | | 公開日 | 2009-07-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Mol.Cancer Ther., 8, 2009
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