1WSO
 
 | | The solution structures of human Orexin-A | | 分子名称: | Orexin-A | | 著者 | Ikegami, T, Takai, T. | | 登録日 | 2004-11-08 | | 公開日 | 2004-11-30 | | 最終更新日 | 2019-12-25 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor
J.Pept.Sci., 12, 2006
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8XZ2
 | | The structural model of a homodimeric D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria | | 分子名称: | D-alanyl-D-alanine dipeptidase | | 著者 | Konuma, T, Takai, T, Tsuchiya, C, Nishida, M, Hashiba, M, Yamada, Y, Shirai, H, Motoda, Y, Nagadoi, A, Chikaishi, E, Akagi, K, Akashi, S, Yamazaki, T, Akutsu, H, Oe, A, Ikegami, T. | | 登録日 | 2024-01-20 | | 公開日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria.
Protein Sci., 33, 2024
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1WRF
 | | Refined solution structure of Der f 2, The Major Mite Allergen from Dermatophagoides farinae | | 分子名称: | Mite group 2 allergen Der f 2 | | 著者 | Ichikawa, S, Takai, T, Inoue, T, Yuuki, T, Okumura, Y, Ogura, K, Inagaki, F, Hatanaka, H. | | 登録日 | 2004-10-15 | | 公開日 | 2005-04-19 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR Study on the Major Mite Allergen Der f 2: Its Refined Tertiary Structure, Epitopes for Monoclonal Antibodies and Characteristics Shared by ML Protein Group Members
J.Biochem.(Tokyo), 137, 2005
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2RTT
 | | Solution structure of the chitin-binding domain of Chi18aC from Streptomyces coelicolor | | 分子名称: | ChiC | | 著者 | Okumura, A, Uemura, M, Yamada, N, Chikaishi, E, Takai, T, Yoshio, S, Akagi, K, Morita, J, Lee, Y, Yokogawa, D, Suzuki, K, Watanabe, T, Ikegami, T. | | 登録日 | 2013-08-26 | | 公開日 | 2014-08-27 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Chitin-binding domain of chitinase Chi18aC from Streptomyces coelicolor
To be Published
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5F9E
 | | Structure of Protein Kinase C theta with compound 10: 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one | | 分子名称: | 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one, Protein kinase C theta type | | 著者 | Klein, M. | | 登録日 | 2015-12-09 | | 公開日 | 2016-05-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKC theta inhibitors.
Bioorg.Med.Chem., 24, 2016
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6ANL
 | | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors | | 分子名称: | Mitogen-activated protein kinase 14, TAK-715 | | 著者 | Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. | | 登録日 | 2017-08-14 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.
Bioorg. Med. Chem., 26, 2018
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3WQP
 | | Crystal structure of Rubisco T289D mutant from Thermococcus kodakarensis | | 分子名称: | 1,2-ETHANEDIOL, 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Fujihashi, M, Nishitani, Y, Kiriyama, T, Miki, K. | | 登録日 | 2014-01-29 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Mutation design of thermophilic Rubisco based on the three-dimensional structure enhances its activity at ambient temperature
to be published
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5WJJ
 | | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors | | 分子名称: | Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide | | 著者 | Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. | | 登録日 | 2017-07-23 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.
Bioorg. Med. Chem., 26, 2018
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5X9P
 | | Crystal structure of the BCL6 BTB domain in complex with Compound 5 | | 分子名称: | 3-[[4-chloranyl-2-nitro-5-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)amino]phenyl]amino]propanoic acid, B-cell lymphoma 6 protein | | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | | 登録日 | 2017-03-08 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design
Bioorg. Med. Chem., 25, 2017
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5X9O
 | | Crystal structure of the BCL6 BTB domain in complex with Compound 1a | | 分子名称: | 1,2-ETHANEDIOL, 5-[(2-chloranyl-4-nitro-phenyl)amino]-1,3-dihydrobenzimidazol-2-one, B-cell lymphoma 6 protein, ... | | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | | 登録日 | 2017-03-08 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design
Bioorg. Med. Chem., 25, 2017
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2RQR
 | | The solution structure of human DOCK2 SH3 domain - ELMO1 peptide chimera complex | | 分子名称: | Engulfment and cell motility protein 1,Dedicator of cytokinesis protein 2 | | 著者 | Yokoyama, S, Tochio, N, Koshiba, S, Kigawa, T, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2009-10-21 | | 公開日 | 2010-10-27 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3VHL
 | | Crystal structure of the DHR-2 domain of DOCK8 in complex with Cdc42 (T17N mutant) | | 分子名称: | Cell division control protein 42 homolog, Dedicator of cytokinesis protein 8, PHOSPHATE ION | | 著者 | Hanawa-Suetsugu, K, Kukimoto-Niino, M, Nishizak, T, Terada, T, Shirouzu, M, Fukui, Y, Yokoyama, S. | | 登録日 | 2011-08-26 | | 公開日 | 2012-06-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.085 Å) | | 主引用文献 | DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
Blood, 119, 2012
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3A98
 | | Crystal structure of the complex of the interacting regions of DOCK2 and ELMO1 | | 分子名称: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1 | | 著者 | Hanawa-Suetsugu, K, Kukimoto-Niino, M, Sekine, S, Ito, T, Mishima-Tsumagari, C, Terada, T, Shirouzu, M, Fukui, Y, Yokoyama, S. | | 登録日 | 2009-10-21 | | 公開日 | 2010-10-27 | | 最終更新日 | 2019-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3B13
 | | Crystal structure of the DHR-2 domain of DOCK2 in complex with Rac1 (T17N mutant) | | 分子名称: | Dedicator of cytokinesis protein 2, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Hanawa-Suetsugu, K, Kukimoto-Niino, M, Mishima-Tsumagari, C, Terada, T, Shirouzu, M, Fukui, Y, Yokoyama, S. | | 登録日 | 2011-06-24 | | 公開日 | 2012-03-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.006 Å) | | 主引用文献 | Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Proc.Natl.Acad.Sci.USA, 109, 2012
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