3VHL
Crystal structure of the DHR-2 domain of DOCK8 in complex with Cdc42 (T17N mutant)
Summary for 3VHL
Entry DOI | 10.2210/pdb3vhl/pdb |
Descriptor | Dedicator of cytokinesis protein 8, Cell division control protein 42 homolog, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | signal transduction, guanine nucleotide exchang factor, gtpase, signaling protein |
Biological source | Mus musculus (mouse) More |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P60953 |
Total number of polymer chains | 2 |
Total formula weight | 55452.26 |
Authors | Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Nishizak, T.,Terada, T.,Shirouzu, M.,Fukui, Y.,Yokoyama, S. (deposition date: 2011-08-26, release date: 2012-06-20, Last modification date: 2023-11-08) |
Primary citation | Harada, Y.,Tanaka, Y.,Terasawa, M.,Pieczyk, M.,Habiro, K.,Katakai, T.,Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Nishizaki, T.,Shirouzu, M.,Duan, X.,Uruno, T.,Nishikimi, A.,Sanematsu, F.,Yokoyama, S.,Stein, J.V.,Kinashi, T.,Fukui, Y. DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood, 119:4451-4461, 2012 Cited by PubMed: 22461490DOI: 10.1182/blood-2012-01-407098 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.085 Å) |
Structure validation
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