5F9E

Structure of Protein Kinase C theta with compound 10: 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one

Summary for 5F9E

• Entry DOI: 10.2210/pdb5f9e/pdb
• Descriptor: Protein kinase C theta type, 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one (3 entities in total)
• Functional Keywords: kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q04759
• Total number of polymer chains: 2
• Total formula weight: 84709.20

Authors

Klein, M. (deposition date: 2015-12-09, release date: 2016-05-11)

• Primary citation: Katoh, T.,Takai, T.,Yukawa, T.,Tsukamoto, T.,Watanabe, E.,Mototani, H.,Arita, T.,Hayashi, H.,Nakagawa, H.,Klein, M.G.,Zou, H.,Sang, B.C.,Snell, G.,Nakada, Y.; Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKC theta inhibitors.; Bioorg.Med.Chem., 24:2466-2475, 2016; PubMed: 27117263; DOI: 10.1016/j.bmc.2016.04.008

Experimental method

X-RAY DIFFRACTION (2 Å)