5F9E
Structure of Protein Kinase C theta with compound 10: 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protein kinase C theta type | polymer | 353 | 41955.2 | 2 | UniProt (Q04759) Pfam (PF00069) Pfam (PF00433) In PDB | Homo sapiens (Human) | nPKC-theta |
2 | A, B | 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one | non-polymer | 399.4 | 2 | Chemie (5VS) | |||
3 | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A, B: 361 - 706 (UniProt: Q04759)
PDB | External Database | Details |
---|---|---|
Met 360 | - | initiating methionine |
Glu 381 | Ile 381 | conflict |
Glu 538 | Thr 538 | conflict |
His 707 | - | expression tag |
His 708 | - | expression tag |
His 709 | - | expression tag |
His 710 | - | expression tag |
His 711 | - | expression tag |
His 712 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 83910.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 798.9 | |
All* | Total formula weight | 84709.2 |