3B13
Crystal structure of the DHR-2 domain of DOCK2 in complex with Rac1 (T17N mutant)
Summary for 3B13
Entry DOI | 10.2210/pdb3b13/pdb |
Descriptor | Dedicator of cytokinesis protein 2, Ras-related C3 botulinum toxin substrate 1 (3 entities in total) |
Functional Keywords | protein-ptotein complex, lymphocyte chemotaxis, signal tansduction, guanine nucleotide exchange factor, gtpase, protein binding-signaling protein complex, protein binding/signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Endomembrane system; Peripheral membrane protein: Q92608 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P63000 |
Total number of polymer chains | 4 |
Total formula weight | 142696.75 |
Authors | Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Mishima-Tsumagari, C.,Terada, T.,Shirouzu, M.,Fukui, Y.,Yokoyama, S. (deposition date: 2011-06-24, release date: 2012-03-14, Last modification date: 2023-11-01) |
Primary citation | Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Mishima-Tsumagari, C.,Akasaka, R.,Ohsawa, N.,Sekine, S.,Ito, T.,Tochio, N.,Koshiba, S.,Kigawa, T.,Terada, T.,Shirouzu, M.,Nishikimi, A.,Uruno, T.,Katakai, T.,Kinashi, T.,Kohda, D.,Fukui, Y.,Yokoyama, S. Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms. Proc.Natl.Acad.Sci.USA, 109:3305-3310, 2012 Cited by PubMed: 22331897DOI: 10.1073/pnas.1113512109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.006 Å) |
Structure validation
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