3B13

Crystal structure of the DHR-2 domain of DOCK2 in complex with Rac1 (T17N mutant)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Dedicator of cytokinesis protein 2	polymer	431	51105.1	2	UniProt (Q92608) Pfam (PF06920) Pfam (PF20422) Pfam (PF20421)	Homo sapiens (human)
2	B, D (B, D)	Ras-related C3 botulinum toxin substrate 1	polymer	184	20243.2	2	UniProt (P63000) Pfam (PF00071)	Homo sapiens (human)	Cell migration-inducing gene 5 protein, Ras-like protein TC25, p21-Rac1
3	E, F (A, C)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, C: 1196 - 1622 (UniProt: Q92608)

PDB	External Database	Details
Gly 1192	-	expression tag
Ser 1193	-	expression tag
Phe 1194	-	expression tag
Thr 1195	-	expression tag

B, D: 1 - 177 (UniProt: P63000)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Asn 17	Thr 17	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	142696.7
All*	Total formula weight	142696.7

*Water molecules are not included.