2LKZ
 
 | | Solution structure of the second RRM domain of RBM5 | | 分子名称: | RNA-binding protein 5 | | 著者 | Song, Z, Wu, P, Zhang, J, Wu, J, Shi, Y. | | 登録日 | 2011-10-23 | | 公開日 | 2012-08-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets
Biochemistry, 2012
|
|
7LVA
 | | Solution structure of the HIV-1 PBS-segment | | 分子名称: | RNA (103-MER) | | 著者 | Heng, X, Song, Z. | | 登録日 | 2021-02-24 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR, SOLUTION SCATTERING | | 主引用文献 | The three-way junction structure of the HIV-1 PBS-segment binds host enzyme important for viral infectivity.
Nucleic Acids Res., 49, 2021
|
|
7DE9
 | |
1XTN
 | | crystal structure of CISK-PX domain with sulfates | | 分子名称: | SULFATE ION, Serine/threonine-protein kinase Sgk3 | | 著者 | Xing, Y, Liu, D, Zhang, R, Joachimiak, A, Songyang, Z, Xu, W. | | 登録日 | 2004-10-22 | | 公開日 | 2004-11-02 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX)
J.Biol.Chem., 279, 2004
|
|
1XTE
 | | crystal structure of CISK-PX domain | | 分子名称: | Serine/threonine-protein kinase Sgk3 | | 著者 | Xing, Y, Liu, D, Zhang, R, Joachimiak, A, Songyang, Z, Xu, W. | | 登録日 | 2004-10-21 | | 公開日 | 2004-11-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX)
J.Biol.Chem., 279, 2004
|
|
7W4Y
 | | Crystal structure of PDE4D catalytic domain complexed with 33a | | 分子名称: | (2R,4S)-6-ethyl-2-(2-hydroxyethyl)-2,8-dimethyl-4-(2-methylprop-1-enyl)-3,4-dihydropyrano[3,2-c][1,8]naphthyridin-5-one, MAGNESIUM ION, ZINC ION, ... | | 著者 | Huang, Y.-Y, Luo, H.-B. | | 登録日 | 2021-11-29 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.10002947 Å) | | 主引用文献 | Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.
J.Med.Chem., 65, 2022
|
|
7W4X
 | | Crystal structure of PDE4D catalytic domain complexed with 17 | | 分子名称: | (2R,4S)-2-(2-hydroxyethyl)-2,6-dimethyl-4-(2-methylprop-1-enyl)-3,4-dihydropyrano[3,2-c][1,8]naphthyridin-5-one, MAGNESIUM ION, ZINC ION, ... | | 著者 | Huang, Y.-Y, Luo, H.-B. | | 登録日 | 2021-11-29 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.20007324 Å) | | 主引用文献 | Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.
J.Med.Chem., 65, 2022
|
|
7RWR
 | | An RNA aptamer that decreases flavin redox potential | | 分子名称: | FLAVIN MONONUCLEOTIDE, RNA (38-MER) | | 著者 | Gremminger, T, Li, J, Chen, S, Heng, X. | | 登録日 | 2021-08-20 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An RNA aptamer that shifts the reduction potential of metabolic cofactors.
Nat.Chem.Biol., 18, 2022
|
|
8GPY
 | | Crystal structure of Omicron BA.4/5 RBD in complex with a neutralizing antibody scFv | | 分子名称: | Spike protein S1, scFv | | 著者 | Gao, Y.X, Song, Z.D, Wang, W.M, Guo, Y. | | 登録日 | 2022-08-27 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
|
|
7YV4
 | | Crystal structure of human UCHL3 in complex with Farrerol | | 分子名称: | (2~{S})-2-(4-hydroxyphenyl)-6,8-dimethyl-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, Ubiquitin carboxyl-terminal hydrolase isozyme L3 | | 著者 | Mao, Z.Y, Xu, X.J, Zhang, W.T. | | 登録日 | 2022-08-18 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer.
Nat Commun, 14, 2023
|
|
4HHY
 | | Crystal structure of PARP catalytic domain in complex with novel inhibitors | | 分子名称: | (9aR)-1-[(1-{2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl}piperidin-4-yl)carbonyl]-1,2,3,8,9,9a-hexahydro-7H-benzo[de][1,7]naphthyridin-7-one, DI(HYDROXYETHYL)ETHER, Poly [ADP-ribose] polymerase 1, ... | | 著者 | Liu, Q.F, Chen, T.T, Xu, Y.C. | | 登録日 | 2012-10-10 | | 公開日 | 2013-03-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3637 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors.
J.Med.Chem., 56, 2013
|
|
4HHZ
 | | Crystal structure of PARP catalytic domain in complex with novel inhibitors | | 分子名称: | N-{(2S)-1-[4-(4-fluorophenyl)-3,6-dihydropyridin-1(2H)-yl]-1-oxopropan-2-yl}-2-[(9aR)-7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de][1,7]naphthyridin-1-yl]acetamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | | 著者 | Liu, Q.F, Chen, T.T, Xu, Y.C. | | 登録日 | 2012-10-10 | | 公開日 | 2013-03-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7199 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors.
J.Med.Chem., 56, 2013
|
|
6LN1
 | | A natural inhibitor of DYRK1A for treatment of diabetes mellitus | | 分子名称: | 1,3,5,8-tetrakis(oxidanyl)xanthen-9-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | | 著者 | Li, H, Chen, L.X, Zheng, M.Z, Zhang, Q.Z, Zhang, C.L, Wu, C.R, Yang, K.Y, Song, Z.R, Wang, Q.Q, Li, C, Zhou, Y.R, Chen, J.C. | | 登録日 | 2019-12-28 | | 公開日 | 2021-10-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.699 Å) | | 主引用文献 | A natural DYRK1A inhibitor as a potential stimulator for beta-cell proliferation in diabetes.
Clin Transl Med, 11, 2021
|
|
8GOU
 | | Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH003 Fab heavy chain, ... | | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | | 登録日 | 2022-08-25 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
|
|
6O8D
 | | Anti-CD28xCD3 CODV Fab bound to CD28 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-CD28xCD3 CODV Fab Heavy chain, ... | | 著者 | Lord, D.M, Wei, R.R. | | 登録日 | 2019-03-09 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.547 Å) | | 主引用文献 | Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
To Be Published
|
|
6O89
 | | Anti-CD28xCD3 CODV Fab | | 分子名称: | Anti-CD28xCD3 CODV-Fab Heavy chain, Anti-CD28xCD3 CODV-Fab Light chain | | 著者 | Lord, D.M, Wei, R.R. | | 登録日 | 2019-03-09 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
Nat Cancer, 1, 2020
|
|
6TG5
 | |
8YXI
 | | Crystal structure of SFTSV Gn in complex with a neutralizing antibody 40C10 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelopment polyprotein, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yang, P, Guo, Y, Zhang, N. | | 登録日 | 2024-04-02 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV.
Plos Pathog., 20, 2024
|
|
2L22
 | |
1MP6
 | |
7X08
 | | S protein of SARS-CoV-2 in complex with 2G1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | | 著者 | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | | 登録日 | 2022-02-21 | | 公開日 | 2022-03-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD.
Cell Discov, 8, 2022
|
|
7YVN
 | | Omicron BA.4/5 SARS-CoV-2 S in complex with TH281 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH281 Fab heavy chain, ... | | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | | 登録日 | 2022-08-19 | | 公開日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
|
|
7YVP
 | | Omicron BA.4/5 SARS-CoV-2 S in complex with TH272/281 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH272 Fab heavy chain, ... | | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | | 登録日 | 2022-08-19 | | 公開日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
|
|
7YVG
 | | Omicron BA.4/5 SARS-CoV-2 S in complex with TH132 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH132 Fab heavy chain, ... | | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | | 登録日 | 2022-08-19 | | 公開日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
|
|
7YVK
 | | Omicron BA.4/5 SARS-CoV-2 S in complex with TH272 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH272 Fab heavy chain, ... | | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | | 登録日 | 2022-08-19 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
|
|
