7W4X

Crystal structure of PDE4D catalytic domain complexed with 17

Summary for 7W4X

• Entry DOI: 10.2210/pdb7w4x/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: camp-specific 3', 5'-cyclic phosphodiesterase 4d, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86414.35

Authors

Huang, Y.-Y.,Luo, H.-B. (deposition date: 2021-11-29, release date: 2022-03-16, Last modification date: 2023-11-29)

• Primary citation: Song, Z.,Huang, Y.Y.,Hou, K.Q.,Liu, L.,Zhou, F.,Huang, Y.,Wan, G.,Luo, H.B.,Xiong, X.F.; Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.; J.Med.Chem., 65:4238-4254, 2022; PubMed: 35188767; DOI: 10.1021/acs.jmedchem.1c02058

Experimental method

X-RAY DIFFRACTION (2.20007326465 Å)