7W4Y
Crystal structure of PDE4D catalytic domain complexed with 33a
Summary for 7W4Y
Entry DOI | 10.2210/pdb7w4y/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | camp-specific 3', 5'-cyclic phosphodiesterase 4d, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 86470.46 |
Authors | Huang, Y.-Y.,Luo, H.-B. (deposition date: 2021-11-29, release date: 2022-03-16, Last modification date: 2023-11-29) |
Primary citation | Song, Z.,Huang, Y.Y.,Hou, K.Q.,Liu, L.,Zhou, F.,Huang, Y.,Wan, G.,Luo, H.B.,Xiong, X.F. Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J.Med.Chem., 65:4238-4254, 2022 Cited by PubMed: 35188767DOI: 10.1021/acs.jmedchem.1c02058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.10002940118 Å) |
Structure validation
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