7OQH
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![BU of 7oqh by Molmil](/molmil-images/mine/7oqh) | CryoEM structure of the transcription termination factor Rho from Mycobacterium tuberculosis | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Transcription termination factor Rho | 著者 | Saridakis, E, Vishwakarma, R, Lai Kee Him, J, Martin, K, Simon, I, Cohen-Gonsaud, M, Coste, F, Bron, P, Margeat, E, Boudvillain, M. | 登録日 | 2021-06-03 | 公開日 | 2022-02-09 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism. Commun Biol, 5, 2022
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3EUN
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4JBS
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![BU of 4jbs by Molmil](/molmil-images/mine/4jbs) | Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 in complex with PHOSPHINIC PSEUDOTRIPEPTIDE inhibitor. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 2, ... | 著者 | Saridakis, E, Birtley, J, Stratikos, E, Mavridis, I.M. | 登録日 | 2013-02-20 | 公開日 | 2013-12-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.789 Å) | 主引用文献 | Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proc.Natl.Acad.Sci.USA, 110, 2013
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6SHG
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![BU of 6shg by Molmil](/molmil-images/mine/6shg) | Diffraction data for RoAb13 crystal co-crystallised with PIYDIN and its RoAb13 structure | 分子名称: | Antibody RoAb13 Heavy Chain, Antibody RoAb13 Light Chain | 著者 | Saridakis, E, Helliwell, J.R, Govada, L, Chain, B, Morgan, M, Kassen, S.C, Chayen, N.E. | 登録日 | 2019-08-06 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.35050821 Å) | 主引用文献 | X-ray crystallography based model of the antibody RoAb13 bound to peptidomimetics of the HIV receptor chemokine receptor CCR5 To Be Published
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5J6S
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![BU of 5j6s by Molmil](/molmil-images/mine/5j6s) | Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand | 分子名称: | (2S)-N~1~-benzyl-2-[(4-fluorophenyl)methyl]-N~3~-hydroxypropanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Saridakis, E, Giastas, P, Mpakali, A, Deprez-Poulain, R, Stratikos, E. | 登録日 | 2016-04-05 | 公開日 | 2017-03-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. ACS Med Chem Lett, 8, 2017
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5K1V
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![BU of 5k1v by Molmil](/molmil-images/mine/5k1v) | Crystal structure of Endoplasmic Reticulum aminopeptidase 2 (ERAP2) in complex with a diaminobenzoic acid derivative ligand. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 2, ... | 著者 | Saridakis, E, Papakyriakou, A, Giastas, P, Mpakali, A, Mavridis, I.M, Stratikos, E. | 登録日 | 2016-05-18 | 公開日 | 2017-03-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.897 Å) | 主引用文献 | Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. ACS Med Chem Lett, 8, 2017
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5NHI
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3EXY
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7NW3
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![BU of 7nw3 by Molmil](/molmil-images/mine/7nw3) | X-ray crystallographic study of PIYDIN, which contains the truncation determinants of binding PI and N, bound to RoAb13, a CCR5 antibody | 分子名称: | Antibody RoAb13 Heavy Chain, Antibody RoAb13 Light Chain, Region from C-C chemokine receptor type 5 N-terminal domain | 著者 | Saridakis, E, Helliwell, J.R, Govada, L, Chayen, N.E. | 登録日 | 2021-03-16 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.200011 Å) | 主引用文献 | X-ray crystallographic studies of RoAb13 bound to PIYDIN, a part of the N-terminal domain of C-C chemokine receptor 5. Iucrj, 8, 2021
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5CU5
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![BU of 5cu5 by Molmil](/molmil-images/mine/5cu5) | Crystal structure of ERAP2 without catalytic Zn(II) atom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 2, ... | 著者 | Saridakis, E, Mathioudakis, N, Giastas, P, Mavridis, I.M, Stratikos, E. | 登録日 | 2015-07-24 | 公開日 | 2015-09-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2. J.Biol.Chem., 290, 2015
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4IP1
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4IP6
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6YDX
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![BU of 6ydx by Molmil](/molmil-images/mine/6ydx) | Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor | 分子名称: | 1,2-ETHANEDIOL, 2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mpakali, A, Saridakis, E, Giastas, P, Stratikos, E. | 登録日 | 2020-03-21 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor. Acs Med.Chem.Lett., 11, 2020
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4E36
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![BU of 4e36 by Molmil](/molmil-images/mine/4e36) | Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 variant N392K | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Birtley, J.R, Saridakis, E, Pegias, P, Stratikos, E, Mavridis, I.M. | 登録日 | 2012-03-09 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing. J.Immunol., 189, 2012
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3SE6
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![BU of 3se6 by Molmil](/molmil-images/mine/3se6) | Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Birtley, J.R, Saridakis, E, Stratikos, E, Mavridis, I.M. | 登録日 | 2011-06-10 | 公開日 | 2011-12-21 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | 主引用文献 | The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing. Biochemistry, 51, 2012
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4S2S
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![BU of 4s2s by Molmil](/molmil-images/mine/4s2s) | Crystal Structure of Fab fragment of monoclonal antibody RoAb13 | 分子名称: | RoAb13 Fab Heavy chain, RoAb13 Fab Light chain | 著者 | Chain, B, Arnold, J, Akthar, S, Noursadeghi, M, Lapp, T, Ji, C, Naider, D, Zhang, Y, Govada, L, Saridakis, E, Chayen, N.E. | 登録日 | 2015-01-22 | 公開日 | 2015-06-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody. Plos One, 10, 2015
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5MJ6
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![BU of 5mj6 by Molmil](/molmil-images/mine/5mj6) | Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | 著者 | Mpakali, A, Stratikos, E, Saridakis, E, Giastas, P. | 登録日 | 2016-11-30 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity. J. Med. Chem., 60, 2017
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3PFU
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![BU of 3pfu by Molmil](/molmil-images/mine/3pfu) | N-terminal domain of Thiol:disulfide interchange protein DsbD in its reduced form | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Thiol:disulfide interchange protein dsbD | 著者 | Mavridou, D.A.I, Saridakis, E, Ferguson, S.J, Redfield, C. | 登録日 | 2010-10-29 | 公開日 | 2011-05-04 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Oxidation state-dependent protein-protein interactions in disulfide cascades J.Biol.Chem., 286, 2011
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7NJZ
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![BU of 7njz by Molmil](/molmil-images/mine/7njz) | X-ray crystallography study of RoAb13 which binds to PIYDIN, a part of the CCR5 N terminal domain | 分子名称: | Antibody RoAb13 Heavy Chain, Antibody RoAb13 Light Chain, Region from C-C chemokine receptor type 5 N-terminal domain | 著者 | Helliwell, J.R, Chayen, N, Saridakis, E, Govada, L. | 登録日 | 2021-02-17 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | X-ray crystallographic studies of RoAb13 bound to PIYDIN, a part of the N-terminal domain of C-C chemokine receptor 5. Iucrj, 8, 2021
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4Z7I
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![BU of 4z7i by Molmil](/molmil-images/mine/4z7i) | Crystal structure of insulin regulated aminopeptidase in complex with ligand | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DG025 transition-state analogue enzyme inhibitor, ... | 著者 | Mpakali, A, Saridakis, E, Harlos, K, Zhao, Y, Stratikos, E. | 登録日 | 2015-04-07 | 公開日 | 2015-08-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | 主引用文献 | Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing. J Immunol., 195, 2015
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5AB2
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![BU of 5ab2 by Molmil](/molmil-images/mine/5ab2) | Crystal structure of aminopeptidase ERAP2 with ligand | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mpakali, A, Giastas, P, Saridakis, E, Mavridis, I.M, Stratikos, E. | 登録日 | 2015-07-31 | 公開日 | 2015-09-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.729 Å) | 主引用文献 | Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (Er) Aminopeptidase 2. J.Biol.Chem., 290, 2015
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5C97
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![BU of 5c97 by Molmil](/molmil-images/mine/5c97) | Insulin regulated aminopeptidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucyl-cystinyl aminopeptidase, ... | 著者 | Mpakali, A, Saridakis, E, Harlos, K, Zhao, Y, Stratikos, E. | 登録日 | 2015-06-26 | 公開日 | 2015-08-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing. J Immunol., 195, 2015
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5AB0
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![BU of 5ab0 by Molmil](/molmil-images/mine/5ab0) | Crystal structure of aminopeptidase ERAP2 with ligand | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mpakali, A, Giastas, P, Saridakis, E, Stratikos, E. | 登録日 | 2015-07-31 | 公開日 | 2015-09-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (Er) Aminopeptidase 2. J.Biol.Chem., 290, 2015
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2ZVS
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![BU of 2zvs by Molmil](/molmil-images/mine/2zvs) | Crystal structure of the 2[4FE-4S] ferredoxin from escherichia coli | 分子名称: | IRON/SULFUR CLUSTER, Uncharacterized ferredoxin-like protein yfhL | 著者 | Giastas, P, Mavridis, M.I. | 登録日 | 2008-11-18 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Insight into the protein and solvent contributions to the reduction potentials of [4Fe-4S]2+/+ clusters: crystal structures of the Allochromatium vinosum ferredoxin variants C57A and V13G and the homologous Escherichia coli ferredoxin J.Biol.Inorg.Chem., 14, 2009
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