6YDX

Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor

Summary for 6YDX

Entry DOI	10.2210/pdb6ydx/pdb
Descriptor	Leucyl-cystinyl aminopeptidase, TETRAETHYLENE GLYCOL, PHOSPHATE ION, ... (13 entities in total)
Functional Keywords	aminopeptidase, antigen presentation, complex, irap, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	216168.70
Authors	Mpakali, A.,Saridakis, E.,Giastas, P.,Stratikos, E. (deposition date: 2020-03-21, release date: 2020-07-22, Last modification date: 2024-01-24)
Primary citation	Mpakali, A.,Saridakis, E.,Giastas, P.,Maben, Z.,Stern, L.J.,Larhed, M.,Hallberg, M.,Stratikos, E. Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor. Acs Med.Chem.Lett., 11:1429-1434, 2020 Cited by PubMed: 32676150 DOI: 10.1021/acsmedchemlett.0c00172 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation