6YDX
Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Leucyl-cystinyl aminopeptidase | polymer | 912 | 104217.7 | 2 | UniProt (Q9UIQ6) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (Human) | Cystinyl aminopeptidase,Insulin-regulated membrane aminopeptidase,Insulin-responsive aminopeptidase,IRAP,Oxytocinase,OTase,Placental leucine aminopeptidase,P-LAP |
| 2 | C, E, F, G, I (C, E, F, G, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D, H (D, H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | J, W (A, B) | 2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid | non-polymer | 560.7 | 2 | Chemie (ONN) | |||
| 5 | K, X (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | AA, BA, CA, L, M... (B, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 7 | Q (A) | SUCCINIC ACID | non-polymer | 118.1 | 1 | Chemie (SIN) | |||
| 8 | DA, EA, FA, R, S (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 9 | T (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 10 | U (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 11 | V (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 12 | GA (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 13 | HA, IA (A, B) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A, B: 155 - 1025 (UniProt: Q9UIQ6)
| PDB | External Database | Details |
|---|---|---|
| Met 124 | - | initiating methionine |
| Gly 125 | - | expression tag |
| Ile 126 | - | expression tag |
| Leu 127 | - | expression tag |
| Pro 128 | - | expression tag |
| Ser 129 | - | expression tag |
| Pro 130 | - | expression tag |
| Gly 131 | - | expression tag |
| Asn 132 | - | expression tag |
| Pro 133 | - | expression tag |
| Ala 134 | - | expression tag |
| Leu 135 | - | expression tag |
| Leu 136 | - | expression tag |
| Ser 137 | - | expression tag |
| Leu 138 | - | expression tag |
| Val 139 | - | expression tag |
| Ser 140 | - | expression tag |
| Leu 141 | - | expression tag |
| Leu 142 | - | expression tag |
| Ser 143 | - | expression tag |
| Val 144 | - | expression tag |
| Leu 145 | - | expression tag |
| Leu 146 | - | expression tag |
| Met 147 | - | expression tag |
| Gly 148 | - | expression tag |
| Cys 149 | - | expression tag |
| Val 150 | - | expression tag |
| Ala 151 | - | expression tag |
| Glu 152 | - | expression tag |
| Thr 153 | - | expression tag |
| Gly 154 | - | expression tag |
| Arg 1026 | - | expression tag |
| Thr 1027 | - | expression tag |
| Glu 1028 | - | expression tag |
| Thr 1029 | - | expression tag |
| Ser 1030 | - | expression tag |
| Gln 1031 | - | expression tag |
| Val 1032 | - | expression tag |
| Ala 1033 | - | expression tag |
| Pro 1034 | - | expression tag |
| Ala 1035 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 208435.4 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3295.1 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 4438.2 | |
| All* | Total formula weight | 216168.7 |
