4JBS
Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 in complex with PHOSPHINIC PSEUDOTRIPEPTIDE inhibitor.
Summary for 4JBS
Entry DOI | 10.2210/pdb4jbs/pdb |
Related | 3SE6 4E36 |
Descriptor | Endoplasmic reticulum aminopeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | thermolysin-like catalytic domain, hydrolase, aminopeptidase, zinc binding, endoplasmic reticulum, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 227482.98 |
Authors | Saridakis, E.,Birtley, J.,Stratikos, E.,Mavridis, I.M. (deposition date: 2013-02-20, release date: 2013-12-11, Last modification date: 2023-09-20) |
Primary citation | Zervoudi, E.,Saridakis, E.,Birtley, J.R.,Seregin, S.S.,Reeves, E.,Kokkala, P.,Aldhamen, Y.A.,Amalfitano, A.,Mavridis, I.M.,James, E.,Georgiadis, D.,Stratikos, E. Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proc.Natl.Acad.Sci.USA, 110:19890-19895, 2013 Cited by PubMed: 24248368DOI: 10.1073/pnas.1309781110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.789 Å) |
Structure validation
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