4OW2
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5JMC
| Receptor binding domain of Botulinum neurotoxin A in complex with rat SV2C | 分子名称: | Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C | 著者 | Yao, G, Zhang, S, Mahrhold, S, Lam, K, Stern, D, Bagramyan, K, Perry, K, Kalkum, M, Rummel, A, Dong, M, Jin, R. | 登録日 | 2016-04-28 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat.Struct.Mol.Biol., 23, 2016
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5JLV
| Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Yao, G, Zhang, S, Mahrhold, S, Lam, K, Stern, D, Bagramyan, K, Perry, K, Kalkum, M, Rummel, A, Dong, M, Jin, R. | 登録日 | 2016-04-27 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat.Struct.Mol.Biol., 23, 2016
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3R4S
| Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules | 分子名称: | Botulinum neurotoxin type C1, N-acetyl-alpha-neuraminic acid, N-acetyl-beta-neuraminic acid | 著者 | Strotmeier, J, Gu, S, Jutzi, S, Mahrhold, S, Zhou, J, Pich, A, Bigalke, H, Rummel, A, Jin, R, Binz, T. | 登録日 | 2011-03-17 | 公開日 | 2011-06-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites. Mol.Microbiol., 81, 2011
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3R4U
| Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules | 分子名称: | Botulinum neurotoxin type C1 | 著者 | Strotmeier, J, Gu, S, Jutzi, S, Mahrhold, S, Zhou, J, Pich, A, Bigalke, H, Rummel, A, Jin, R, Binz, T. | 登録日 | 2011-03-17 | 公開日 | 2011-06-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites. Mol.Microbiol., 81, 2011
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4QD2
| Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex | 分子名称: | CALCIUM ION, Cadherin-1, Hemagglutinin component HA17, ... | 著者 | Lee, K, Zhong, X, Gu, S, Kruel, A, Dorner, M.B, Perry, K, Rummel, A, Dong, M, Jin, R. | 登録日 | 2014-05-13 | 公開日 | 2014-06-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science, 344, 2014
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2NM1
| Structure of BoNT/B in complex with its protein receptor | 分子名称: | Botulinum neurotoxin type B, Synaptotagmin-2 | 著者 | Jin, R, Rummel, A, Binz, T, Brunger, A.T. | 登録日 | 2006-10-20 | 公開日 | 2006-12-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity. Nature, 444, 2006
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4LO3
| HA17-HA33-LacNac | 分子名称: | HA-17, HA-33, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose | 著者 | Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R. | 登録日 | 2013-07-12 | 公開日 | 2013-10-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.249 Å) | 主引用文献 | Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity. Plos Pathog., 9, 2013
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4LO0
| Apo HA17-HA33 | 分子名称: | HA-17, HA-33 | 著者 | Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R. | 登録日 | 2013-07-12 | 公開日 | 2013-10-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.055 Å) | 主引用文献 | Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity. Plos Pathog., 9, 2013
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4LO2
| HA17-HA33-Lac | 分子名称: | HA-17, HA-33, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | 著者 | Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R. | 登録日 | 2013-07-12 | 公開日 | 2013-10-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.254 Å) | 主引用文献 | Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity. Plos Pathog., 9, 2013
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4LO1
| HA17-HA33-Gal | 分子名称: | HA-17, HA-33, beta-D-galactopyranose | 著者 | Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R. | 登録日 | 2013-07-12 | 公開日 | 2013-10-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.254 Å) | 主引用文献 | Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity. Plos Pathog., 9, 2013
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4LO4
| Apo HA-70 | 分子名称: | CHLORIDE ION, HA-70 | 著者 | Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R. | 登録日 | 2013-07-12 | 公開日 | 2013-10-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.871 Å) | 主引用文献 | Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity. Plos Pathog., 9, 2013
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4LO5
| HA70-alpha2,3-SiaLC | 分子名称: | CHLORIDE ION, HA-70, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R. | 登録日 | 2013-07-12 | 公開日 | 2013-10-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity. Plos Pathog., 9, 2013
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4LO6
| HA70-alpha2,6-SiaLC | 分子名称: | CHLORIDE ION, HA-70, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose | 著者 | Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R. | 登録日 | 2013-07-12 | 公開日 | 2013-10-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity. Plos Pathog., 9, 2013
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4LO7
| HA70(D3)-HA17-HA33 | 分子名称: | HA-17, HA-33, HA-70 | 著者 | Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R. | 登録日 | 2013-07-12 | 公開日 | 2013-10-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.73 Å) | 主引用文献 | Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity. Plos Pathog., 9, 2013
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4LO8
| HA70(D3)-HA17 | 分子名称: | HA-17, HA-70 | 著者 | Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R. | 登録日 | 2013-07-12 | 公開日 | 2013-10-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity. Plos Pathog., 9, 2013
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4OUJ
| Crystal structure of HA33B-Lac | 分子名称: | Hemagglutinin component HA33, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Lee, K, Lam, K.-H, Perry, K, Rummel, A, Jin, R. | 登録日 | 2014-02-17 | 公開日 | 2014-06-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex. Biochem.Biophys.Res.Commun., 446, 2014
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3V0A
| 2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BoNT/A, CALCIUM ION, ... | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | 登録日 | 2011-12-07 | 公開日 | 2012-03-14 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science, 335, 2012
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3V0C
| 4.3 angstrom crystal structure of an inactive BoNT/A (E224Q/R363A/Y366F) | 分子名称: | BoNT/A, ZINC ION | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | 登録日 | 2011-12-07 | 公開日 | 2012-03-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science, 335, 2012
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3V0B
| 3.9 angstrom crystal structure of BoNT/Ai in complex with NTNHA | 分子名称: | BoNT/A, CALCIUM ION, NTNH, ... | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | 登録日 | 2011-12-07 | 公開日 | 2012-03-14 | 最終更新日 | 2013-09-25 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science, 335, 2012
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5V38
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5WIX
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6FBL
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7UIB
| Crystal structure of BoNT/E receptor binding domain in complex with SV2, VHH, and sialic acid | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-beta-neuraminic acid, ... | 著者 | Liu, Z, Jin, R, Chen, P. | 登録日 | 2022-03-29 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2. Nat Commun, 14, 2023
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7UIA
| Crystal structure of BoNT/E receptor binding domain in complex with SV2 and VHH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | 著者 | Liu, Z, Jin, R, Chen, P. | 登録日 | 2022-03-28 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2. Nat Commun, 14, 2023
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