8IIU
 
 | | anti-VEGF nanobody | | 分子名称: | SULFATE ION, anti-VEGF nanobody | | 著者 | Qian, F, Zhu, S.Q. | | 登録日 | 2023-02-24 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
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8IJZ
 | | anti-VEGF mutant | | 分子名称: | anti-VEGF nanobody | | 著者 | Qian, F, Zhu, S.Q. | | 登録日 | 2023-02-28 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | | 主引用文献 | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
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8IJS
 | | anti-VEGF nanobody mutant | | 分子名称: | ZINC ION, anti-VEGF nanobody | | 著者 | Qian, F, Zhu, S.Q. | | 登録日 | 2023-02-28 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | | 主引用文献 | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
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1KD7
 | | Crystal structure of an extracellular domain fragment of human BAFF | | 分子名称: | TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13B | | 著者 | Karpusas, M, Cachero, T.G, Qian, F, Boriack-Sjodin, A, Mullen, C, Strauch, K, Hsu, Y.-M, Kalled, S.L. | | 登録日 | 2001-11-12 | | 公開日 | 2002-11-12 | | 最終更新日 | 2017-02-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure of Extracellular Human BAFF, a TNF Family Member that Stimulates B Lymphocytes
J.Mol.Biol., 315, 2002
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3LQ8
 | | Structure of the kinase domain of c-Met bound to XL880 (GSK1363089) | | 分子名称: | Hepatocyte growth factor receptor, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | | 著者 | Lougheed, J.C, Stout, T.J. | | 登録日 | 2010-02-08 | | 公開日 | 2010-05-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases.
Cancer Res., 69, 2009
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7T92
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3KJ4
 | | Structure of rat Nogo receptor bound to 1D9 antagonist antibody | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab fragment 1D9 heavy chain, ... | | 著者 | Silvian, L.F. | | 登録日 | 2009-11-02 | | 公開日 | 2010-09-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering.
Biotechnol Appl Biochem, 57, 2010
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6AR4
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3LKJ
 | | Small Molecule Inhibition of the TNF Family Cyokine CD40 Ligand Through a Subunit Fracture Mechanism | | 分子名称: | (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand | | 著者 | Silvian, L.F, Whitty, A. | | 登録日 | 2010-01-27 | | 公開日 | 2011-02-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism.
Acs Chem.Biol., 6, 2011
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6L5M
 | | Crystal structure of human DEAD-box RNA helicase DDX21 in complex with AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, Nucleolar RNA helicase 2 | | 著者 | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | | 登録日 | 2019-10-24 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Adv Sci, 7, 2020
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6L5N
 | | Crystal structure of human DEAD-box RNA helicase DDX21 at post-unwound state | | 分子名称: | MAGNESIUM ION, Nucleolar RNA helicase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | | 登録日 | 2019-10-24 | | 公開日 | 2020-06-17 | | 最終更新日 | 2020-08-12 | | 実験手法 | X-RAY DIFFRACTION (2.242 Å) | | 主引用文献 | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Adv Sci, 7, 2020
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6L5L
 | | Crystal structure of human DEAD-box RNA helicase DDX21 at apo state | | 分子名称: | MAGNESIUM ION, Nucleolar RNA helicase 2 | | 著者 | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | | 登録日 | 2019-10-24 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Adv Sci, 7, 2020
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6L5O
 | | Crystal structure of human DEAD-box RNA helicase DDX21 at post-hydrolysis state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | | 登録日 | 2019-10-24 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Adv Sci, 7, 2020
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6CO3
 | | aducanumab abeta complex | | 分子名称: | ALA-GLU-PHE-ARG-HIS-ASP, Fab heavy chain, Fab light chain, ... | | 著者 | Arndt, J.W. | | 登録日 | 2018-03-10 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.384 Å) | | 主引用文献 | Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
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6CNR
 | | aducanumab apo Fab | | 分子名称: | Aducanumab heavy chain, Aducanumab light chain, SULFATE ION | | 著者 | Arndt, J.W. | | 登録日 | 2018-03-08 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
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4AW5
 | | Complex of the EphB4 kinase domain with an oxindole inhibitor | | 分子名称: | (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(5-methoxy-1H-benzimidazol-2-yl)(phenyl)methylidene]-1,3-dihydro-2H-indol-2-one, EPHRIN TYPE-B RECEPTOR 4 | | 著者 | Till, J.H, Stout, T.J. | | 登録日 | 2012-05-31 | | 公開日 | 2012-08-01 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | The Design, Synthesis, and Biological Evaluation of Potent Receptor Tyrosine Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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2X6G
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2X6L
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2X69
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2BDN
 | | Crystal structure of human MCP-1 bound to a blocking antibody, 11K2 | | 分子名称: | Antibody heavy chain 11K2, Antibody light chain 11K2, Small inducible cytokine A2 | | 著者 | Boriack-Sjodin, P.A, Rushe, M, Reid, C, Jarpe, M, van Vlijmen, H, Bailly, V. | | 登録日 | 2005-10-20 | | 公開日 | 2006-06-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody.
Protein Eng.Des.Sel., 19, 2006
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7CK1
 | | Crystal structure of arabidopsis CESA3 catalytic domain | | 分子名称: | Cellulose synthase A catalytic subunit 3 [UDP-forming],Cellulose synthase A catalytic subunit 3 [UDP-forming], MANGANESE (II) ION | | 著者 | Qiao, Z, Gao, Y.G. | | 登録日 | 2020-07-15 | | 公開日 | 2021-03-17 | | 最終更新日 | 2021-03-31 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7CK3
 | | Crystal structure of Arabidopsis CESA3 catalytic domain | | 分子名称: | Cellulose synthase A catalytic subunit 3 [UDP-forming],Cellulose synthase A catalytic subunit 3 [UDP-forming] | | 著者 | Qiao, Z, Gao, Y.G. | | 登録日 | 2020-07-15 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7CK2
 | | Crystal structure of Arabidopsis CESA3 catalytic domain with UDP-Glucose | | 分子名称: | Cellulose synthase A catalytic subunit 3 [UDP-forming],Cellulose synthase A catalytic subunit 3 [UDP-forming], MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE | | 著者 | Qiao, Z, Gao, Y.G. | | 登録日 | 2020-07-15 | | 公開日 | 2021-03-17 | | 最終更新日 | 2021-03-31 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
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8HK7
 | | Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, CALCIUM ION, ... | | 著者 | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | | 登録日 | 2022-11-25 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8K3S
 | | Structure of PKD2-F604P complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ... | | 著者 | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | | 登録日 | 2023-07-16 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.
Proc.Natl.Acad.Sci.USA, 121, 2024
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