6AR4

Crystal structure of PICK1 in complex with the small molecule inhibitor 1o

Summary for 6AR4

• Entry DOI: 10.2210/pdb6ar4/pdb
• Descriptor: PRKCA-binding protein, N-[4-(4-bromophenyl)-1-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carbonyl]-3-cyclopropyl-L-alanine (3 entities in total)
• Functional Keywords: pdz domain pdz inhibitor, actin binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 28187.63

Authors

Marcotte, D. (deposition date: 2017-08-21, release date: 2018-08-22, Last modification date: 2023-10-04)

• Primary citation: Lin, E.Y.S.,Silvian, L.F.,Marcotte, D.J.,Banos, C.C.,Jow, F.,Chan, T.R.,Arduini, R.M.,Qian, F.,Baker, D.P.,Bergeron, C.,Hession, C.A.,Huganir, R.L.,Borenstein, C.F.,Enyedy, I.,Zou, J.,Rohde, E.,Wittmann, M.,Kumaravel, G.,Rhodes, K.J.,Scannevin, R.H.,Dunah, A.W.,Guckian, K.M.; Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.; Sci Rep, 8:13438-13438, 2018; PubMed: 30194389; DOI: 10.1038/s41598-018-31680-3

Experimental method

X-RAY DIFFRACTION (1.69 Å)