4AW5
Complex of the EphB4 kinase domain with an oxindole inhibitor
Summary for 4AW5
Entry DOI | 10.2210/pdb4aw5/pdb |
Related | 2BBA 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD |
Descriptor | EPHRIN TYPE-B RECEPTOR 4, (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(5-methoxy-1H-benzimidazol-2-yl)(phenyl)methylidene]-1,3-dihydro-2H-indol-2-one (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P54760 |
Total number of polymer chains | 1 |
Total formula weight | 33390.37 |
Authors | Till, J.H.,Stout, T.J. (deposition date: 2012-05-31, release date: 2012-08-01, Last modification date: 2024-05-01) |
Primary citation | Kim, M.H.,Tsuhako, A.L.,Co, E.W.,Aftab, D.T.,Bentzien, F.,Chen, J.,Cheng, W.,Engst, S.,Goon, L.,Klein, R.R.,Le, D.T.,Mac, M.,Parks, J.J.,Qian, F.,Rodriquez, M.,Stout, T.J.,Till, J.H.,Won, K.A.,Wu, X.,Michael Yakes, F.,Yu, P.,Zhang, W.,Zhao, Y.,Lamb, P.,Nuss, J.M.,Xu, W. The Design, Synthesis, and Biological Evaluation of Potent Receptor Tyrosine Kinase Inhibitors. Bioorg.Med.Chem.Lett., 22:4979-, 2012 Cited by PubMed: 22765894DOI: 10.1016/J.BMCL.2012.06.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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