4AW5
Complex of the EphB4 kinase domain with an oxindole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | EPHRIN TYPE-B RECEPTOR 4 | polymer | 291 | 32896.8 | 1 | UniProt (P54760) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | EPHRIN B4, HEPATOMA TRANSMEMBRANE KINASE, TYROSINE-PROTEIN KINASE TYRO11 |
| 2 | B (A) | (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(5-methoxy-1H-benzimidazol-2-yl)(phenyl)methylidene]-1,3-dihydro-2H-indol-2-one | non-polymer | 493.6 | 1 | Chemie (30K) | |||
| 3 | C (A) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 81 - 366 (UniProt: P54760)
| PDB | External Database | Details |
|---|---|---|
| Pro 76 | - | expression tag |
| Trp 77 | - | expression tag |
| Gly 78 | - | expression tag |
| Ser 79 | - | expression tag |
| Met 80 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32896.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 493.6 | |
| All* | Total formula weight | 33390.4 |
