6AFK
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![BU of 6afk by Molmil](/molmil-images/mine/6afk) | Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor | 分子名称: | N-{(3S)-1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl}-1H-indole-2-carboxamide, S-ADENOSYLMETHIONINE, tRNA (guanine-N(1)-)-methyltransferase | 著者 | Zhong, W, Koay, A, Wong, Y.W, Sahili, A.E, Nah, Q, Kang, C, Poulsen, A, Chionh, Y.K, McBee, M, Matter, A, Hill, J, Lescar, J, Dedon, P.C. | 登録日 | 2018-08-08 | 公開日 | 2019-08-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors. Acs Infect Dis., 5, 2019
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7DT2
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7DXL
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![BU of 7dxl by Molmil](/molmil-images/mine/7dxl) | |
5YJO
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![BU of 5yjo by Molmil](/molmil-images/mine/5yjo) | |
6IJL
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5XWR
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![BU of 5xwr by Molmil](/molmil-images/mine/5xwr) | Crystal Structure of RBBP4-peptide complex | 分子名称: | Histone-binding protein RBBP4, MET-SER-ARG-ARG-LYS-GLN-ALA-LYS-PRO-GLN-HIS-ILE | 著者 | Jobichen, C, Lui, B.H, Daniel, G.T, Sivaraman, J. | 登録日 | 2017-06-30 | 公開日 | 2018-07-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5YIG
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![BU of 5yig by Molmil](/molmil-images/mine/5yig) | Crystal structure of Streptococcus pneumonia ParE with inhibitor | 分子名称: | 1-ethyl-3-[5-[2-[(1S,5R)-3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-5-(2-oxidanylidene-3H-1,3,4-oxadiazol-5-yl)pyridin-3-yl]-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]pyridin-2-yl]urea, DNA topoisomerase 4 subunit B | 著者 | Cherian, J, Tan, Y, Hill, J. | 登録日 | 2017-10-04 | 公開日 | 2018-09-05 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. Eur J Med Chem, 157, 2018
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6JLR
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6ILZ
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![BU of 6ilz by Molmil](/molmil-images/mine/6ilz) | Crystal structure of PKCiota in complex with inhibitor | 分子名称: | 2-amino-5-[3-(piperazin-1-yl)phenyl]-N-(pyridin-4-yl)pyridine-3-carboxamide, Protein kinase C iota type | 著者 | Baburajendran, N, Hill, J. | 登録日 | 2018-10-21 | 公開日 | 2019-06-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.261 Å) | 主引用文献 | Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. Acs Med.Chem.Lett., 10, 2019
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5BOD
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![BU of 5bod by Molmil](/molmil-images/mine/5bod) | Crystal structure of Streptococcus pneumonia ParE inhibitor | 分子名称: | (2R)-N-[3-(3,5-dimethylphenyl)-1H-pyrazol-5-yl]-1,4-dioxane-2-carboxamide, DNA topoisomerase 4 subunit B | 著者 | Tan, Y.W, Chen, G, Hung, A.W, Hill, J. | 登録日 | 2015-05-27 | 公開日 | 2015-06-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Application of Fragment-based Drug Discovery against DNA GyraseB to be published
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5BOC
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5DQE
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5DQ8
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4J3L
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![BU of 4j3l by Molmil](/molmil-images/mine/4j3l) | Tankyrase 2 in complex with 3-chloro-N-(2-methoxyethyl)-4-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzamide | 分子名称: | 3-chloro-N-(2-methoxyethyl)-4-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzamide, SULFATE ION, Tankyrase-2, ... | 著者 | Jansson, A.E, Larsson, E.A, Nordlund, P.L. | 登録日 | 2013-02-05 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Fragment-based ligand design of novel potent inhibitors of tankyrases. J.Med.Chem., 56, 2013
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4J1Z
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4J21
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![BU of 4j21 by Molmil](/molmil-images/mine/4j21) | Tankyrase 2 in complex with 7-(4-amino-2-chlorophenyl)-4-methylquinolin-2(1H)-one | 分子名称: | 7-(4-amino-2-chlorophenyl)-4-methylquinolin-2(1H)-one, SULFATE ION, Tankyrase-2, ... | 著者 | Jansson, A.E, Larsson, E.A, Nordlund, P.L. | 登録日 | 2013-02-04 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Fragment-based ligand design of novel potent inhibitors of tankyrases. J.Med.Chem., 56, 2013
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7CC2
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4J22
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![BU of 4j22 by Molmil](/molmil-images/mine/4j22) | Tankyrase 2 in complex with 3-chloro-4-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)-N-[2-(morpholin-4-yl)ethyl]benzamide | 分子名称: | 3-chloro-4-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)-N-[2-(morpholin-4-yl)ethyl]benzamide, SULFATE ION, Tankyrase-2, ... | 著者 | Jansson, A.E, Larsson, E.A, Nordlund, P.L. | 登録日 | 2013-02-04 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Fragment-based ligand design of novel potent inhibitors of tankyrases. J.Med.Chem., 56, 2013
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4IUE
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![BU of 4iue by Molmil](/molmil-images/mine/4iue) | Tankyrase in complex with 7-(2-fluorophenyl)-4-methyl-1,2-dihydroquinolin-2-one | 分子名称: | 7-(2-fluorophenyl)-4-methylquinolin-2(1H)-one, SULFATE ION, Tankyrase-2, ... | 著者 | Jansson, A.E, Larsson, E.A, Nordlund, P.L. | 登録日 | 2013-01-21 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Fragment-based ligand design of novel potent inhibitors of tankyrases. J.Med.Chem., 56, 2013
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4J3M
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![BU of 4j3m by Molmil](/molmil-images/mine/4j3m) | Tankyrase 2 in complex with 3-chloro-4-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzoic acid | 分子名称: | 3-chloro-4-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzoic acid, GLYCEROL, SULFATE ION, ... | 著者 | Jansson, A.E, Larsson, E.A, Nordlund, P.L. | 登録日 | 2013-02-06 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Fragment-based ligand design of novel potent inhibitors of tankyrases. J.Med.Chem., 56, 2013
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3W51
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![BU of 3w51 by Molmil](/molmil-images/mine/3w51) | Tankyrase in complex with 2-hydroxy-4-methylquinoline | 分子名称: | 4-methylquinolin-2-ol, SULFATE ION, Tankyrase-2, ... | 著者 | Jansson, A.E, Larsson, E.A, Nordlund, P.L. | 登録日 | 2013-01-18 | 公開日 | 2013-07-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fragment-based ligand design of novel potent inhibitors of tankyrases. J.Med.Chem., 56, 2013
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